Chakaravarthi, P (2017) An open clinical study on Sooli Kanam (Childhood Bronchial Asthma) in children with the evaluation of siddha trial drug Athimadhura Chooranam. Masters thesis, Government Siddha Medical College, Chennai.
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Abstract
The aim of the study is to assess the efficacy of trial drug “ATHIMATHURA CHOORANAM” for “SOOLI KANAM" (CHILDHOOD BRONCHIAL ATHMA) without any adverse effects. The etiology, pathogenesis, signs and symptoms of Soolikanam have been correlated with that of childhood bronchial asthma with evidence of literature. Clinical diagnosis and selection of cases based on clinical features described in Balavagadam text book and also using questionnaire. The internal medicine chosen for treatment and management of Soolikanam was Athimathura chooranam 500mg, twice a day, after food with honey. The trial drug selection based on its siddha pharmacological action to pacify the deranged vetham, pitham and kabam and also due to its Immunomodulatory, Bronchodilatory and Antihiastamatic effect of the ingrediants. 40 cases were diagnosed with Sooli kanam clinically observed for clinical diagnosis, laboratory diagnosis, peak expiratory flow rate during the treatment and the results were dealt in the proforma. Laboratory diagnosis was done by modern methods of examinations. The treatment covers administration of trial drug according to the age and also includes pranayamam. The documentation of observation made during the clinical study showed that the drug is clinically more effective. The biochemical analysis Sterility test by pour plate method of Athimathura chooranam shows no growth / colonies like E-coli, Salmonella, Staphylococcus Aureus and Peudomonas Aeruginosa. In the pharmacological analysis, the trial drug Athimathura chooranam had significant Anti-histamine, Bronchodilator and Immunomodulator activity which controlling the airway hyper responsiveness help to improve the patients quality of life. The physico chemical analysis of the trial drug shows the Loss on drying at 1050C (%) – 16.7 ± 2.06, Total Ash (%) – 6.12 ± 3.76, Acid insoluble Ash – 0.56 ± 0.14, Water soluble Ah – 1.14 ± 0.19, Alcohol Soluble Extractive – 20.35 ± 1.53, Water soluble Extractive – 15.54 ± 1.5, PH – 7, So it shows the safe and effectiveness of the drug. With these benefits of ATHIMATHURA CHOORANAM is more effective drug for SOOLIKANAM (CHILDHOOD BRONCHIAL ATHMA). CONCLUSION: Bronchial asthma is a heterogeneous pulmonary disorder characterized by recurrent episodes of cough, breathlessness and wheezing, which may resolve spontaneously or after the use of bronchodilator medication. Asthma is the leading chronic disease among children in most industrialized countries, increasing prevalence and its impact in reducing the quality of life in children. In this clinical study Athimathura chooranam were taken as Internal medicine respectively. Soolikanam (Bronchial asthma) occurs due to alteration in Kaba kutram. In Athimathura chooranam most of the drugs have Kaarpu suvai, Kaarpu suvai are decrease the Kaba kuttram. So I choose this drug is more effective to reduce the Kaba kuttram in Bronchial asthma. The treatment of Soolikanam with Athimathura chooranam has showed Good response with no adverse effect and ensure to be safe, effective and simple to administration. The drugs have antihistamine, Bronchodilator and anti-microbial activity. Statistically it is concluded that the treatment was effective and significant. Clinical results were found to be good improvement was found in 75% of cases, moderate in 15% of cases and Poor in 10% of cases. The clinical trial conducted in selected patients was satisfactory and encouraging.
| Item Type: | Thesis (Masters) |
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| Additional Information: | (Reg.No. 321414102) |
| Uncontrolled Keywords: | Sooli Kanam ; Childhood Bronchial Asthma ; children ; siddha trial drug ; Athimadhura Chooranam ; clinical study. |
| Subjects: | AYUSH > Kuzhanthai Maruthuvam |
| Depositing User: | Kambaraman B |
| Date Deposited: | 24 Sep 2018 03:02 |
| Last Modified: | 24 Sep 2018 03:02 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/9610 |
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