Neenu Oliver, John (2018) To study the role of diffusion weighted magnetic resonance imaging for predicting clinical and pathologic response to neoadjuvant chemoradiotherapy in esophageal cancer. Masters thesis, Christian Medical College, Vellore.
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Abstract
OBJECTIVES: To evaluate the role of serial diffusion weighted magnetic resonance imaging (DW-MRI) for predicting clinical and pathologic response to neoadjuvant chemoradiotherapy in esophageal cancer. METHODS: This is a prospective cohort study conducted in our institution comprising 24 consecutive patients with biopsy proven, locally advanced esophageal cancer who were planned for neoadjuvant chemoirradiation. All the recruited patients underwent a baseline DW-MRI, another at 10 to14 days and another at the end of radiation. During assessment for surgery, the patients who were deemed surgically inoperable were called as non-responders. Among those who underwent surgery, patients with complete pathological response (pCR) were called responders whereas those with a poor response were called as non-responders. The Apparent Diffusion Coefficient (ADC) values (mean and minimum) and the ΔADC values were calculated. RESULTS : The ADC values measured in the interim scan was significantly higher among patients with pathological complete response compared to the non-responders (mean p=0.013, minimum p=0.001). However, the ΔADC values did not significantly correlate with the pathological response. Hence, it was concluded that serial DW-MRIs performed in patients undergoing chemoradiotherapy is feasible and may be used to predict treatment response at surgery. Also, a significant rise in ADC values in the interim scan obtained at 10-14 days, may predict a pathological complete response at surgery.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Diffusion weighted MRI ; neoadjuvant chemoradiotherapy ; esophageal cancer ; pathological response. |
| Subjects: | MEDICAL > Radio Therapy |
| Depositing User: | Subramani R |
| Date Deposited: | 22 Jul 2018 01:45 |
| Last Modified: | 22 Jul 2018 01:45 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/8971 |
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