Kanagashree, I (2015) A Comparative Study of Autonomic Functions and Serum Levels of Vascular Endothelial Growth Factor in Psoriatic Skin and Psoriatic Arthritis Patients. Masters thesis, Madras Medical College, Chennai.
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Abstract
AIM OF THE STUDY: To access and compare the Autonomic functions (ANS) and serum levels Vascular Endothelial Growth Factor (VEGF) in Psoriatic skin (Ps) and Psoriatic Arthritis (PsA) patients. MATERIALS AND METHODS: The study contains three study groups containing 15 men and women of age between 20- 40 years with normal resting blood pressure. Those with skin lesions and no clinical evidence of arthritis comes under Ps group and those having clinical evidence of arthritis with or without skin lesions comes under PsA. All the 90 individuals are subjected to 5 minute Resting HRV and Orthostatic, Isometric Hand Grip, Cold Pressor, Deep breathing and Valsalva tests. Serum was collected and VEGF analysed using standard ELISA kit. RESULTS: The patient groups showed increased LF, LF/ HF ratio, serum VEGF and also elevated diastolic blood pressure in isometric hand grip, cold pressor test. The HF, 30/15, E/I and Valsalva ratio. Inter comparison between Ps and PsA is statistically significant. CONCLUSION: ANS dysfunction is present in both Ps and PsA patients in form of sympathetic over activity and parasympathetic withdrawal and elevated serum VEGF levels. The ANS dysfunction is more in PsA and no significance of serum VEGF values between the groups. VEGF value reflects the disease severity.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | ANS functions ; Psoriatic skin ; psoriatic arthritis ; VEGF ; Resting HRV. |
| Subjects: | MEDICAL > Physiology |
| Depositing User: | Punitha K |
| Date Deposited: | 23 May 2018 17:44 |
| Last Modified: | 23 May 2018 17:44 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/8055 |
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