Balachandar, S (2015) A Study of Plasma Fibrinogen Levels in Stroke. Masters thesis, Tirunelveli Medical College, Tirunelveli.
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Abstract
INTRODUCTION: Increased plasma fibrinogen is a risk factor for vascular diseases related to atherosclerosis. Its predictive value in stroke is not well established. We conducted this study to establish the significance of hyperfibrinogenemia with severity and functional outcome of acute stroke. METHODS: We studied 100 patients who got admitted with stroke within 24 hours of symptom onset. We noted the history regarding risk factors and assessed the severity of stroke by Scandinavian stroke scale and functional outcome of stroke by modified Rankin scale at the time of admission and discharge. Plasma fibrinogen was measured in all patients. The values computed and analysed with pearson correlation and chi-square tests. RESULTS: The mean fibrinogen was 405.6 mg/dl. The mean value was increased in patients having ischemic stroke. Patients having hyperfibrinogenemia at the time of admission has increased severity of stroke (p<0.01) as assessed by Scandinavian stroke scale (mean-29.91) and similarly has poor functional outcome as evidenced by increased scores of modified Rankin scale (p<0.01) at the time of admission and discharge.12 patients were expired during the course of stay in hospital. The mean fibrinogen among the dead patients was significantly higher (439.58) as compared to overall mean fibrinogen value. Among the risk factors, although the mean value was increased in smokers, hypertension and diabetes, we could establish a significant relation only with diabetes. CONCLUSION: Increased plasma fibrinogen shortly after ischemic stroke predicts the severity and poor functional outcome of stroke.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | fibrinogen ; stroke severity ; Scandinavian stroke scale ; modified Rankin scale. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Punitha K |
| Date Deposited: | 18 May 2018 18:56 |
| Last Modified: | 19 May 2018 03:26 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/7947 |
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