Govindaraj, C (2015) Prevalence of Inhibitors in Patients with Hemophilia Treated with Factor VIII or IX Transfusion in Coimbatore Medical College Hospital. Masters thesis, Coimbatore Medical Collegel, Coimbatore.
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Abstract
INTRODUCTION: Deficiency or absence of factor VIII or factor IX causes hemophilia A and hemophilia B respectively. According to the level of factor VIII hemophilia is classified into mild, moderate and severe forms. Recent problem in treating patients with hemophilia is development of alloantibodies against factor VIII or IX, also known as inhibitors. This should be suspected if the patient is not responding to replacement of missing factor at therapeutic doses. The objective of the study was to study the prevalence of inhibitors in severe hemophilia patients by using Bethesda assay. METHODOLOGY: This was an observational study. 50 patients with severe hemophilia were selected based on their factor levels. Among them, Hemophilia A contributed to 36 patients, whereas 14 patients had Hemophilia B. Inhibitor assay was done using Bethesda assay. Inhibitor development was analyzed by comparing the various factors which influence the development of inhibitors. RESULTS AND DISCUSSION: Among the patients with severe hemophilia A, 31% had inhibitors, of which 25% had high responding inhibitors and 6% had low responding inhibitors. Among the severe hemophilia B patients, 7% had inhibitors. Small sample size may be a reason for the high prevalence noted in our study. The Mean age of patients with inhibitors and without inhibitors was 19.33 years and 23.63 years respectively. Patients with more than 30 cumulative exposure days to factor concentrates had 53% more risk of developing inhibitors. Patients who were diagnosed earlier and those with family history of inhibitors had significantly higher risk of developing inhibitors during the course of treatment. Patients with inhibitors also had a high bleeding score.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Hemophilia ; factor VIII ; Bethesda assay ; factor IX ; inhibitors. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Punitha K |
| Date Deposited: | 18 May 2018 18:56 |
| Last Modified: | 22 May 2018 16:23 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/7934 |
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