Chandramouli, R K (2015) A Study on Serum Prolactin Levels in CKD Patients and it’s Correlation with Coronary Artery Heart Disease. Masters thesis, Thanjavur Medical College, Thanjavur.
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Abstract
BACKGROUND: In CKD patient’s prolactin clearance & production are altered; this causes Hyperprolactinemia in CKD patients. CKD is associated with increased risk of CAHD.Emerging evidence suggests that prolactin plays a major role in atherosclerotic process. OBJECTIVES: 1. To study the occurrence of Hyperprolactinemia in CKD patients. 2. To study the links between hyperprolactinemia in CKD patients & occurrence of CAHD in them. METHODOLOGY: We conducted an observational study in 50 CKD patients. Fasting serum prolactin levels were measured in them; Incidence of CAHD was evaluated in them using ECG & ECHO. RESULTS: In our study among the 50 CKD patients, 28 patients had Hyperprolactinemia which is about 56% of the study population. Statistical analysis using T test showed significant association to exist between Hyperprolactinemia & CKD. In our study among the 28 CKD patients with Hyperprolactinemia 17 patients were diagnosed to have CAHD; this is about 60.7%. Statistical analysis using Chi Square test showed significant association to exist between Hyperprolactinemia in CKD patients & Occurence of CAHD among them. CONCLUSION: Serum prolactin levels are increased in patients with CKD. This hyperprolactinemia in CKD patients is associated with increased risk of CAHD in them.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Prolactin ; Hyperprolactinemia ; CKD ; CAHD. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Punitha K |
| Date Deposited: | 18 May 2018 18:54 |
| Last Modified: | 21 May 2018 00:36 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/7914 |
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