Renuka, P (2015) A Study on Altered Total Plasma Homocysteine Level and Lipid Profile in Newly Diagnosed Hypothyroid Individuals. Masters thesis, Madras Medical College, Chennai.
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Abstract
One of the major complication of hypothyroidism is atherosclerosis and cardiovascular disease. Hyperhomocysteinemia is an important and independent risk factor for atherosclerosis. Hypothyroidism decreases hepatic levels of enzymes which converts homocysteine to methionine that leads to increase in homocysteine level in the circulation of hypothyroid individuals. The aim of the study was to assess fasting total plasma homocysteine level in recently diagnosed hypothyroidism. The study included thirty recently diagnosed hypothyroid individuals, thirty treated hypothyroidism and thirty apparently healthy subjects with age and sex matched. The study group was selected after obtaining ethical committee clearance and consent from subjects attending outpatient department of Endocrinology, Madras Medical College, Chennai. Thyroid profile, homocysteine and lipid profile were measured in fasting blood samples. Total plasma homocysteine levels was significantly more in recently diagnosed hypothyroidism compared to controls and treated hypothyroidism with p value 0.006. By this study we confirmed hyperhomocysteinemia in hypothyroidism which may lead to atherosclerosis. Hypothyroidism is one of the treatable cause for hyperhomocysteinemia. Lipid profile was altered in recently diagnosed hypothyroidism. Total cholesterol, triglycerides, LDL cholesterol and HDL cholesterol were high in recently diagnosed hypothyroidism compared to controls and treated hypothyroidism. Lipid profile was highly significant between the study groups with the p value <0.001 except HDL cholesterol. During treatment with thyroxine hypothyroid patients should be monitored for lipid profile, total plasma homocysteine levels. In hypothyroidism estimation of total plasma homocysteine level is may be used as screening test to identify and monitor cardiovascular risk.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Hypothyroidism ; Homocysteine ; Lipid profile. |
| Subjects: | MEDICAL > Biochemistry |
| Depositing User: | Punitha K |
| Date Deposited: | 06 May 2018 15:12 |
| Last Modified: | 06 May 2018 15:12 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/7550 |
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