Prabhakar, A T (2013) Epidemiology and Risk factors of Distal Sensory Neuropathy in a Cohort of HIV Positive Individuals on First Line Combination Anti-Retroviral Therapy - A Prospective Observational Study. Masters thesis, Christian Medical College, Vellore.
|
Text
160101113prabhakar.pdf Download (995kB) | Preview |
Abstract
OBJECTIVES : To prospectively follow up a cohort of anti-retroviral therapy naïve HIV infected South Indian adults started on combination anti-retroviral therapy to assess the epidemiology of Distal Sensory Polyneuropathy and to assess the risk factors for Distal Sensory Polyneuropathy in patients on first line combination anti-retroviral therapy. METHODS : A cohort of cART naïve HIV positive patients who have been screened to rule out neuropathy using conventional nerve conduction studies were followed up from the initiation of cART for a mean period of 59 months. Patients were recruited to the study and they were evaluated at base line, three months, six months and then on yearly for the development of neuropathy. The assessment was by historical symptoms, clinical examination, conventional nerve conduction study and sympathetic skin response. RESULTS : Of the fifty six cART naive HIV positive patients screened 23.2% of the ART were detected to have DSP. The prevalence of symptomatic DSP amongst cART naïve patients with HIV was detected to be 5.4%. Low baseline CD4 cell count, advancing age, increasing duration of disease and advanced clinical stage of disease were identified as risk factors for DSP amongst the cART naive patients. During the follow up of forty patients on first line generic cART over a period of 59 months eight patients 20% were detected to have a DSP. The prevalence of symptomatic DSP while on first line cART was found to be 7.5%. The risk factors for the development of DSP while on cART were an age greater than 40, a persistently low CD4 count of less than 500 and weight loss while on cART. Absent SSR was associated with symptomatic DSP as well exposure to a Stavudine based cART regimen.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Epidemiology ; Risk factors ; Distal Sensory Neuropathy ; Cohort of HIV Positive Individuals ; First Line Combination ; Anti-Retroviral Therapy ; Prospective Observational Study. |
| Subjects: | MEDICAL > Neurology |
| Depositing User: | Kambaraman B |
| Date Deposited: | 03 Jul 2017 08:17 |
| Last Modified: | 03 Jul 2017 08:41 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/728 |
Actions (login required)
 |
View Item |
