Andrew Chellakumar, Fenn (2015) Disease outcome of oral and oropharyngeal squamous cell carcinoma based on virological risk stratification. Masters thesis, Christian Medical College, Vellore.
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Abstract
Introduction: Oral Cancer is the 9th most common cancer worldwide among men; it is the 6th most common cancer in the developing nations. Oral cancer ranks 2nd most common cancer among men in the South Central Asia region of which India is a part. In Chennai, head and neck cancers form about 20% of the cancer burden among men and a little less than 10% among women. The incidence rates of Oropharyngeal and Oral Cancers for men, of the total head and neck cancers, were 10% and 45% respectively. Traditional aetiology for head and neck cancers included tobacco and alcohol usage. But recently, infection with HPV was found to be an aetiological agent. Aims and Objectives The aim of our study was to study the relationship of HPV infection to oral and oropharyngeal cancers. We wished to study the association between risk factors of HNSCC and HPV positivity, to evaluate the occurrence of premalignant lesions associated with HPV and to study the effect of HPV positivity on the aggressiveness of the disease and response to treatment. Methods and Materials Based on the literature, we chose to divide the patients into 2 groups – HPV positive and negative. Sample size was calculated to be 18 in each group. All patients who were proven squamous cell carcinoma of the oral cavity and the oropharynx, treatment naïve and who did not have distant metastasis were included in the study. Patients with recurrence/metastasis were excluded from the study. Association of premalignant conditions of leukoplakia, erythroplakia and submucous fibrosis were looked at in relation to HPV infection. Various factors such as tobacco/alcohol use, HPV infection and response to therapy were looked at in oral/oropharyngeal cancers. Results 49 patients were available for HPV analysis, of which 2 patients’ samples tested positive for HPV. There was no association found between HPV positivity and response to therapy. Also, both patients who were HPV positive had used tobacco. One patient who was HPV positive had associated Submucous Fibrosis. Conclusion There is need to do more research in this field to clarify the role of HPV in Oral/Oropharyngeal Cancers in the Indian setting. Future studies looking at HPV would require having strict inclusion criteria. Molecular profiling of these cancers based on p16 and p53 may further shed light on this emerging area of research.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Oral and Oropharyngeal squamous cell; carcinoma; Virological Risk Stratification |
| Subjects: | MEDICAL > Radio Therapy |
| Depositing User: | Punitha K |
| Date Deposited: | 28 Mar 2018 06:01 |
| Last Modified: | 28 Mar 2018 06:01 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/6701 |
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