Gibi, Mathew (2017) Development and Characterization of Morinda Citrifolia Phytosomal Gel for Topical Application. Masters thesis, KMCH College of Pharmacy, Coimbatore.
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Abstract
INTRODUCTION:Herbal medicine is one of the oldest and most universal system of health care system. The advancement in the field of herbal drug delivery started recently with the aim to manage human diseases efficiently. World Health Organization (WHO) estimates that 80% of the world populations presently use herbal medicine for primary health care. Every nation is seeking health care beyond the traditional boundaries of modern medicine; turning to self medication in the form of herbal remedies. Modern herbal medicine is based upon the combination of traditional knowledge, clinical experience, understanding of medicinal science and scientific evidence of herbal medicine. People are slowly and gradually switching to alternative forms of medicine. One of these many alternative therapies include herbal system of medicine. It is made of from an extract taken from the plant parts (leaf, root, flower and bark). They are absolutely natural and safe form of curing illness form occurring repeatedly. They help in curing the ailment and are also known to prevent the illness from occurring repeatedly. Herbal medicines may have long curing periods, but they eradicate the illness from it and prevent any future episodes of the same. AIM AND OBJECTIVES: Morinda citrifolia L. (Rubiaceae), commonly known as Noni, has been extensively used in folk medicine by the Polynesians for over 2000 years. It is having a high demand as an alternative medicine due to its use as antioxidant, anti fungal , anti bacterial, anti-inflammatory, liver protective, anticancer, analgesic, immunomodulatory, anti viral and wound healing effects etc. Phytochemical investigations have shown that noni contains a number of phenolic compounds, in particular, coumarins , flavonoids, and iridoids which are reported to have various pharmacological effects . However, these phytoconstituents are poorly absorbed either due to their large molecular size, which cannot be absorbed by passive diffusion or due to their poor lipid solubility, thus severely limiting their ability to transport across lipid-rich biological membranes, resulting in their poor bioavailability. Phytosomes are vesicular drug delivery systems which incorporate plant extracts or water soluble phytoconstituents into phospholipids to produce lipid compatible molecular complexes. They provide better absorption and bioavailability than the conventional herbal extracts. The aim of the present study was to prepare and evaluate topical phytosomal gel of Woodfordia fruticosa with an objective to increase its bioavailability and therapeutic efficacy. The objectives of the study are: • To formulate phytosomes containing Morinda citrifolia extract • To characterize the prepared phytosomes using various methods like , entrapment efficiency , percentage yield , solubility, drug content , in vitro drug diffusion studies , exvivo permeation study vesicular shape, and physical stability of phytosomes, To prepare phytosomal gel containing Morinda citrifolia extract To carry out pH, spreadability coefficient, extrudability, drug content, rheological studies and in-vitro drug diffusion study and drug release kinetic data analysis of the optimized formulation of phytosomal gel containing Morinda citrifolia extract. To carry out the stability studies on the optimized formulation of phytosomes as per ICH guidelines. SUMMARY: Morinda citrifolia L. (Noni) have been used for thousands of years for the treatment of many health problems including cancer, cold, diabetes, flu, hypertension and pain. Scientific investigations reported its antioxidant, antifungal , anti bacterial, anti-inflammatory, liver protective, anticancer, analgesic, immunomodulatory, anti viral and wound healing activities. Even though extracts have reported several therapeutic benefits, but extraction of individual compound from it often exhibits limited clinical utility as the synergistic effect of various natural ingredients gets lost and the various phytoconstituents present in it are poorly absorbed either due to their large molecular size, which cannot be absorbed by passive diffusion or due to their poor lipid solubility, thus severely limiting their ability to transport across lipid-rich biological membranes, resulting in their poor bioavailability. Phytosome technology has proved to be beneficial in providing better absorption and bioavailability of polar biomolecules over conventional herbal extracts. Hence the present study was aimed to prepare and evaluate topical phytosomal gel of Morinda citrifolia with an objective to increase its bioavailability and therapeutic efficacy. CONCLUSION: 1. The phytosomal formulations were subjected to various studies like percentage yield , solubility, drug content , entrapment efficiency, in vitro drug release studies. 2. The optimized formulation was further subjected to ex-vivo skin permeation study and SEM analysis. 3. The prepared gel formulations was evaluated for pH, spreadability coefficient, extrudability, drug content, rheological studies and in-vitro drug diffusion study. 4. Release kinetic data revealed that the gel followed Higuchi model kinetics with non- Fickian diffusion of drug. 5. Stability studies were carried out at accelerated temperature 40oC ± 20C, 70% RH ±5% for 45 days. There were no significant changes in the homogeneity, drug content, pH, spreadability, extrudability, viscosity and in-vitro diffusion profile.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.261510901 |
| Uncontrolled Keywords: | Morinda Citrifolia Phytosomal Gel ; Topical Application |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 23 Mar 2018 10:13 |
| Last Modified: | 26 Mar 2018 05:59 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/6486 |
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