Mohamed Aboobacker Siddique, M (2017) Evaluation of Toxicity and Antidiabetic Activity of Ethanolic Extract of Aerial Parts of Anisomeles Malabarica (L.) Against Dexamethasone Induced Hyperglycemia in Wistar Albino Rats. Masters thesis, Mohamed Sathak A.J. College of Pharmacy, Chennai.
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Abstract
AIM: The aim of the present study was to evaluate the anti diabetic activity of ethanolic extract of aerial parts of Anisomeles malabarica Linn. OBJECTIVE: The objectives of the present research are as follows: To prepare and standardize the ethanolic extracts of roots of Anisomeles malabarica Linn. To establish the safety of the extract by carrying out acute and sub acute toxicity studies and investigating the behavioral changes in Wistar albino rats. To investigate the antidiabetic effect ethanolic extracts of roots of Anisomeles malabarica Linn. against dexamethasone-induced insulin resistance in wistar albino rats.SUMMARY & CONCLUSION:In the current research, we have investigated the effect of Anisomeles malabarica Linn on dexamethasone induced insulin resistance models. Various biochemical estimations like glucose, cholesterol. Triglycerides, LDL and HDL levels and antioxidant estimations like TBARS SOD, CAT, and GSH were estimated in two different doses of Anisomeles malabarica Linn (100 and 200mg/kg p.o.) and then compared with the standard and induced compound. Anisomeles malabarica Linn at a dose of 100mg/kg and 200mg/kg prevented the development of hyperglycemia, hypercholesteremia and hypertriglyceridemia in dexamethasone induced insulin resistance models. Oral administration of Anisomeles malabarica Linn 100mg/kg and 200mg/kg reduces serum glucose, triglyceride, total cholesterols and LDL concentration and improve the concentration of HDL in dexamethasone administered rats. The lignin Anisomeles malabarica Linn showed significant anti-diabetic effect in rats after oral administration. The present study demonstrated that Anisomeles malabarica Linn could be useful in Management of diabetes associated with abnormalities in lipid profiles. Further study need to isolate, identify the active compounds and find out the possible mechanism of actions.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Toxicity ; Antidiabetic Activity ; Ethanolic Extract ; Aerial Parts ; Anisomeles Malabarica (L.) Against Dexamethasone Induced Hyperglycemia in Wistar Albino Rats |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Ravindran C |
| Date Deposited: | 08 Jan 2018 05:59 |
| Last Modified: | 08 Jan 2018 05:59 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/5364 |
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