Nisar, PM (2017) Evaluation of Antihyperlipidaemic and Antioxident Activity of Artocarpus Heterophyllus Stem Extract. Masters thesis, Padmavathi College of Pharmacy and Research Institute, Dharmapuri.
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Abstract
AIM : To successfully evaluate the antihyperlipidaemic and antioxidant activity of Artocarpus heterophyllus stem extract on High fat diet-induced hypercholesterolemia and triton induced hyperlipidaemia models. OBJECTIVE: To conduct a literature survey for establishing the relavence of the study. To Collection and authenticate of Artocarpus heterophyllus stem. To successfully extract the dried stem of Artocarpus heterophyllus using suitable solvents. To evaluate toxicological profile of the extract. To characterize the anti-hyperlipidemic effect as well as antioxidant property of the extract.DISCUSSION:Artocarpus heterophyllus is a large, evergreen tree found generally in Western Ghats of India, Malaysia and also found in central and eastern Africa, south-eastern Asia, the Caribbean, Florida, Brazil, Australia, Puerto Rico and many Pacific Islands. Different parts of the plant, studied revealed antibacterial, anti-inflammatory, antidiabetic, antioxidant and immune modulatory properties. The antioxidant screening shows that that it showed reducing power to DPPH radicals. But the efficiency showed is far below from Vitamin C. Considering super oxide radical scavenging studies, ethanolic extract shows similar percentage of inhibition comparing the standard drug. Accute phase toxicological studies reports no mortality or signs of toxicity up to the limit dose of 2000 mg/kg in treated rats. All 24 rats were normal throughout the study and survived until the end of the 14-day experiment period. The preliminary phytochemical screening of plant bark extracts indicate in presence of flavonoid, alkaloid, tannins, terpenoids and glycosides may accounts antioxidant and anti-hyprelipidaemic potential. The presences of various phyto-constituents like alkaloids, flavonoids, terpenoids, phytosterols, saponinsetc, were responsible for the specified pharmacological effects. Alcoholic extracts shows more number of phytoconstituents.. Oral administration of ethanolic bark extracts significantly reduced the cholesterol, triglycerides, low density lipoproteins, very low density lipoproteins and significantly increased the HDL – cholesterol level as compared with high cholesterol diet induced hyperlipidemic animals. The results were significant with the p value (p<0.001). Triton WR 1339 is the non-ionic detergent, induces acute hyperlipidemiaby raising cholesterol levels raise 2-3 times within 24 hours of administration.. The mechanism of the Triton induced hypercholesterolemia is thought to be due to increased hepatic synthesis of cholesterol through the ability of Triton to interfere with the uptake of plasma lipids by the tissue.In triton induced study results shows serum lipid paremeters in animals were significantly reduced (p<0.01,) by seven days treatment with AAHP at dose levels 200 mg/kg and 400 mg/kg, when compared with control group 400 mg/kg of AAHP group animals has shown significant (p<0.001) compared with control group. At this time, an increased level of HDL was also observed. CONCLUSION: The preliminary phytochemical screening revealed the presence of sterols, flavonoids, polyphenolics and fixed oil in ethanolic extract and sterols, proteins, polyphenolics, pectin’s in the aqueous extract. The results indicates that the extract possess anti-oxidant properties, but when compared with a standard marketed drug, in superoxide radical scavenging activity studies the percentage inhibition shown by the extract was far less comparing standard drug and in DPPH radical reducing studies we observed a similar percentage inhibition to that of standard drug. Ethanolic extract showed decreased blood lipids in hyperlipidemic rats when compared to normal and standard groups The bark extracts shows a decreased in the TC, TG, and LDL and an increase in HDL in biphasic model of the Triton induced hyperlipidaemia rats, Diet induced hyperlipidemic rats and also in Normocholesteremic rats. The present study concludes that the extracts of Artocarpusheterophyllus bark possess significant anti-oxidant and anti-hyperlipidemic activity.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Antihyperlipidaemic ; Antioxident Activity ; Artocarpus Heterophyllus Stem Extract |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Ravindran C |
| Date Deposited: | 08 Jan 2018 06:03 |
| Last Modified: | 08 Jan 2018 06:03 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/5351 |
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