Niruban, Chakkaravarthi (2015) Neuroprotective Effect of Hydroalcoholic Extract of Boerhaavia Diffusa Linn against MPTP Induced Neurodegenartion in Rats. Masters thesis, K.M. College of Pharmacy, Madurai.
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Abstract
The present study was undertaken to find out the potential activity of Boerhaavia diffusa against breast cancer and their effects on MPTP induced breast Neurodegenaration in rats. From time immemorial mankind's efforts and ultimate aim have been to seek eternal happiness. And his endeavour has been to overcome and seek appropriate remedies for things that stand in his way. Plants have played a weighty role in maintaining human health and improving the quality of human life for thousands of years and have several precious components of medicines, seasonings, beverages, cosmetics, and dyes. Herbal medicines are based on the premise that plants contain natural substance that can promote health and alleviate illness. In recent times focus on plant research has increased all over the world and large evidence has collected to show immense potential of medicinal plants used in various traditional systems. Today we are witnessing a great deal of public interest in the use of herbal remedies. Many western drugs had their origin in plant extract. There are many herbs, which are preponderantly used to treat cardiovascular problems, liver disorder, central nervous system, digestive system, metabolic disorders and for Neuroprotective effects. Given their potential to generate significant therapeutic effect, they can be useful as drug or supplement in the treatment in the management of many diseases. Herbal drug or medicinal plants, their extract and isolated compounds have demonstrated spectrum of biological activities. Such have been used and continued to be used as medicine in folk-fore or food supplement for various disorders. Boerhaavia diffusa (Punarnava) is one of the most famous medicinal plants in the treatment of a large number of human ailments is mentioned in Ayurveda, Charaka Samhita, and Sushrita Samhita. This work explains the evidence-based information regarding the pharmacological activity of this plant. It has many ethnobotanical uses (the leaves are used as vegetable; the root juice is used to cure asthma, urinary disorders, leukorrhea, rheumatism, and encephalitis). The Boerhaavia diffusa plant contains a large number of such compounds as flavonoids, alkaloids, steroids, triterpenoids, lipids, lignins, carbohydrates, proteins, and glycoproteins. Punarnavine, boeravinone, hypoxanthine 9-L-arabinofuranoside, ursolic acid, punarnavoside etc. Now this investigation was undertaken to study the effect of Boerhaavia diffusa on MPTP induced Neurodegenaration and also planned to study the changes occuring in the enzymic and non enzymic system such as super oxide dismutase, catalyase, glutathione peroxide and lipid peroxidation level present in the living body. CONCLUSION:In summary, findings of the present study provide evidence that HAEBD at the dose of 400mg/kg p.o alleviates behavioral deficits. It also reduced the oxidative parameter and enhances the brain antioxidants, significantly prevents the brain from neurotoxic effects. Therefore, Hydroalcoholic extract of Boerhaavia diffusa Linn contains flavanoids and polyphenols was considered as powerful neuroprotective agent could offer a useful support to the Parkinsonism therapy.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Neuroprotective ; Hydroalcoholic Extract ; Boerhaavia Diffusa Linn ; MPTP ; Neurodegenartion ; Rats |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Ravindran C |
| Date Deposited: | 05 Jan 2018 05:37 |
| Last Modified: | 05 Jan 2018 05:37 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/4938 |
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