Suchindra, R (2007) A Comparitive study of efficacy of three different regimens of vaginal misoprostol in first trimester termination of pregnancy. Masters thesis, Madras Medical College, Chennai.
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Abstract
This present randomized controlled study conducted at Government Kasturba Gandhi Hospital for Women and Children, Chennai during the period 2004 –2006 evaluated the efficacy of the three regimens of vaginal misoprostol in the termination of first trimester of pregnancy. Total of 300 women who attended the family planning clinic requesting for first trimester termination of pregnancy were included in the study. The efficacy of three regimens of vaginal misoprostol was compared in terms of Induction – Abortion interval, complete abortion, incomplete abortion and incidence of side effects and the results were statistically analyzed. Observations in this study include, • Most of the patients were in the age group of 21 – 30 years (78%). • 82% of the women were parous, only 18% were nullipara. • Most of the women were belonged to class IV / V Socioeconomic status (85%). • 73% of the patients belonged to 10 – 12 weeks of gestation though they were selected at random basis. • In the study, IA interval was less (16.30 hours) with 600 microgram. • Complete abortion varied in the three groups and was highest in 600 μg group (74%). • Side effects were less in women who received 200μg. None of the women in this group had dizziness and only one patient had diarrhea. Incidence of bleeding was similar in all the three groups. • Mean IA interval using 200μg was 22.22 hours, with 400μg it was 19.57 hours and with 600μg 16.59 hours. • Statistically there is a significant difference in IA interval between and within the three dosage groups (p = 0.000). • There is also a statistically significant difference in IA interval between and with in the gestational age groups (p = 0.027). • There is no significant difference in IA interval between and within the parity by statistical analysis. • Statistically significant difference is there in complete and incomplete abortion between the three regimens. (p= 0.01 and 0.05). • Statistically there is significant difference in the incidence of side effects with the three regimens. CONCLUSION: Induction – Abortion interval is less with 600μg when compared to 400μg and 200μg. • Induction – Abortion interval in 10 – 12 weeks of gestation observed in this is less. • Complete abortion rate was more with 600μg regimen when compared to other two regimens. • Incidence of side effects was less with 200 μg. • There was almost similar incidence of abdominal / uterine cramps and excessive bleeding. Medical management of MTP is a boon to low resource countries like India where infrastructural facilities and trained personnel are at a premium. However, there is scope for misuse of this drug which needs to be curtailed and watched. This is a comparatively inexpensive, easy to administer technique which when used by properly trained persons in a set up with facilities for further management as and when required will go a long way in reducing the unwanted interferences by unscrupulous persons.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Comparitive study ; efficacy ; three different regimens ; vaginal misoprostol ; first trimester termination ; pregnancy. |
| Subjects: | MEDICAL > Obstetrics and Gynaecology |
| Depositing User: | Subramani R |
| Date Deposited: | 03 Dec 2017 11:13 |
| Last Modified: | 09 Dec 2017 02:04 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/4169 |
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