Keerthana Devi, R (2014) Formulation and Evaluation of Transdermal Patches Using Isolated Solasodine from Solanum Surattense for Anti- Inflammatory, Analgesic and Antipyretic Activity. Masters thesis, College of Pharmacy, Madras Medical College, Chennai.
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Abstract
The present study Non-steroidal anti-inflammatory drugs (NSAIDS) are widely used in the treatment of acute and chronic inflammation, pain and fever. But the greatest disadvantage in presently available synthetic drugs is that they cause gastrointestinal irritation and reappearance of symptoms after discontinuation [5,46]. Therefore, there is a dire need for screening and development of novel and better anti-inflammatory, analgesic and anti-pyretic drug that will be effective with better safety profile. Indigenous medicinal plants could be a logical source to find these. Solanum surattense has many therapeutic uses mentioned in Ayurveda, especially Anti-inflammatory property [3]. This is mainly due to the alkaloid solasodine which is found in leaves and berries of the plant S.surattense. This plant is available throughout India and hence I intended to carry out my work to formulate and evaluate the transdermal patches from isolated solasodine of Solanum surattense for anti-inflammatory, analgesic and anti-pyretic activity. Objectives of the study include To standardize the crude drug used for the Isolation. Isolation of solasodine from S.Surattense. Characterization of isolated compound. Formulation of transdermal patches using isolated compound of solasodine. Standardization and evaluation of transdermal patches. Invitro evaluation of Transdermal paches. Skin irritation test of Transdermal patches in rabbits. Invivo evaluation for anti-inflammatory, anti-pyretic and analgesic activity. CONCLUSION: The present study was an attempt to formulate and evaluate the transdermal patches using isolated solasodine for anti-inflammatory, anti-pyretic and analgesic activity. The crude drug was consistent with various identity, quality and purity parameters such as physico-chemical parameters, fluorescence analysis, and heavy metal analysis. The crude drug was used for the isolation of solasodine and formulation of transdermal patches. The patch which shows maximum drug release in in vitro studies were selected for pharmacological evaluation. Transdermal patches containing solasodine shows better anti-inflammatory, anti-pyretic and analgesic activity when compared to synthetic standards used such as indomethacin and aspirin. Thus these patches may be beneficial for the treatment of inflammations, pain, fever, but detailed preclinical and clinical studies are required to establish the use of solasodine transdermal patches as anti-inflammatory, analgesic and anti-pyretic formulation.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Transdermal Patches; Using Isolated Solasodine; Solanum Surattense; Anti- Inflammatory; Analgesic; Antipyretic Activity |
| Subjects: | PHARMACY > Pharmacognosy |
| Depositing User: | Ravindran C |
| Date Deposited: | 20 Oct 2017 07:07 |
| Last Modified: | 20 Oct 2017 07:07 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3723 |
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