Vengatesh, S (2014) Drug Design, Synthesis, Characterization and Biological Studies of Some Novel Heterocyclic Compounds as Anti-Tubercular Agents. Masters thesis, College of Pharmacy, Madras Medical College, Chennai.
|
Text
261215710 Vengatesh S.pdf Download (12MB) | Preview |
Abstract
The present study the literature survey reveals to develop novel and potent cyclopropane mycolic acid synthase – 2 (cmaA – 2) inhibitors with anti-tubercular activity. OBJECTIVE: Identification of the common Pharmacophore responsible for the inhibition of cmaA – 2 using Hiphop module of Catalyst® software 4.11 from Accelrys. Using scaffold hopping technique, generation of 10,000 scaffolds from the drug. Prediction of anti-tubercular activity for the designed using the Hypo refine model and to identify novel and potent cmaA – 2 inhibitor using Lipinski rule of five. The potent cmaA – 2 inhibitors attained as results can be used as lead for drug development. Docking of the lead with various derivatives using Glide software to the target 1KPI. The derivatives of the compounds from the lead molecule which has higher Glide score value were synthesized. Synthesis and characterization Synthesis of substituted imidazole. Synthesis of title compounds Study of physical properties of the synthesized compounds Melting point, Percentage yield, TLC profile, Solubility.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Biological Studies; Novel Heterocyclic Compounds; Anti-Tubercular Agents |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ravindran C |
| Date Deposited: | 20 Oct 2017 07:03 |
| Last Modified: | 20 Oct 2017 07:03 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3717 |
Actions (login required)
 |
View Item |
