Dinesh Kumar, V (2008) Transfersomes as a Carrier for Transdermal Delivery of Acarbose. Masters thesis, Periyar College of Pharmaceutical Sciences for Girls, Tiruchirappalli.
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Abstract
This study was to investigate the possible influence of Acarbose on glucagons like peptide-1 release and gastric emptying in type 2 diabetic patients after mixed test meal. It concluded that hyper-glycaemic type 2 diabetic patients, ingestion of Acarbose with a mixed test meal failed to enhance glucogon like peptide-1 release and did not influence gastric emptying.On the basis of these results, the Acarbose trnasfersomes (Formulation-3) showed better characteristic behaviour. The drug entrapment in formulation – 3 is higher than the other formulations. The diffusion study of Acarbose transfersome gave extended release of the drug which suffices to decreased dose, lesser frequent dose of treatment and more patient compliance. In anti - diabetic studies, the formulation - 3 considerable decrease of blood glucose by topical application, when compared with other formulation. This proved its targeting efficiency. So it was concluded that Acarbose transfersomes (Formulation – 3) was a better and efficient formulation than existing formulations.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Transfersomes; Transdermal; Acarbose |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 25 Sep 2017 06:17 |
| Last Modified: | 25 Sep 2017 06:17 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3295 |
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