Chaitanya Kumar, S (2009) Formulation of Glipizide Time-Controlled Release Tablets By Press Coating Using Hydrophilic and Hydrophobic Polymers – Its In Vitro Dissolution, Time Lag and Kinetic Models. Masters thesis, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore.
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Abstract
The main aim of the work is to achieve time-controlled disintegration with distinct predetermined time lag. To study the effect of formulation of outer shell comprising both hydrophobic polymer and hydrophilic excipients on the time lag of drug release. To find out the suitable weight ratios of hydrophilic excipients, to modulate the time lag of time controlled disintegrating tablets. Studies were under taken on the formulation of glipizide time controlled release tablets by press coating using hydrophilic polymers polyethylene glycol (PEG 6000) and hydroxyl ethyl cellulose (HEC) and hydrophobic polymer ethylcellulose. Here EC/PEG was used in the outer coating layer for E1 formulation and EC/HEC in outer coating layer for E2 formulation. The order of dissolution of glipizide from E1 and E2 formulations Chemical incompatibilities study confirmed that there is no interaction between drug and excipients in the formulation. The weight variations, drug content uniformity, hardness, friability of all the formulated tablets were within the specified requirements. Drug release kinetics confirmed that the glipizide time controlled release formulations were best expressed by Higuchi’s equation. In conclusion, the time lag of press-coated tablet could be modulated by choosing the type and amount of excipient used in the outer shell to achieve the time-controlled disintegration according to the time required The present st tablet can be suitably modulated by formulating the outer shell with ethyl cellulose and polyethylene glycol 6000 or hydroxyl ethyl cellulose.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Glipizide Time-Controlled Release Tablets; Hydrophilic; Hydrophobic Polymers; In Vitro Dissolution;, Time Lag; Kinetic Models |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 25 Sep 2017 05:56 |
| Last Modified: | 25 Sep 2017 05:56 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3277 |
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