Anudeepa, J (2009) Development of Validation of RP – HPLC Method, UV – Spectrophotometric Simultaneous Equation Method Of Drotaverine Hydrochloride and Mefenamic Acid in Combined Tablet Dosage From. Development and Validation of RP – HPLC Method, Uv – Spectrophotometric Simultaneous Equation Method of Olmesartan Medoxomil and Hydrochlorothiazide in Combined Tablet Dosage Form. Masters thesis, College of Pharmacy, Madurai Medical College, Madurai.
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Abstract
Drotaverine Hydrochloride and Mefenamic acid an Antispasmodic and Analgesic drug combination in combined dosage form, is being considered for analysis by UV spectrophotomeric simultaneous equation method as l max of drug is dissimilar and their absorbance ratio lies outside the range 0.1 to 2. The next aim is to develop and validate a reverse phase high performance liquid chromatography in accordance with USP and ICH guidelines for the assay of the active ingredients which would be simple, rapid, efficient and reliable for the analysis of both the drugs in combined dosage form. Olmesartan Medoxomil and Hydrochlorothiazide an Antihypertensive and Diuretic drug combination in combined dosage form, is being considered for analysis by UV spectrophotomeric simultaneous equation method as l max of drug is dissimilar and their absorbance ratio lies outside the range 0.1 to 2. The next aim is to develop and validate a reverse phase high performance liquid chromatography in accordance with USP and ICH guidelines for the assay of the active ingredients which would be simple, rapid, efficient and reliable for the analysis of both the drugs in combined dosage form. Drotaverine hydrochloride and Mefenamic aid in combined tablet dosage form analyzed by UV – spectrophotometric simultaneous equation and Reverse phase high performance liquid chromatography. On comparing these methods Reverse phase high performance liquid chromatography was found to be more precise, accurate, rugged, robust,simple, and rapid than UV spectrophotometric method. Olmesartan medoxomil and hydrochlorothiazide in combined tablet dosage from was analyzed by UV – spectrophotometric simultaneous equation method and Reverse phase high performance liquid chromatography. On comparing these methods Reverse phase high performance chromatography was found to be more precise, accurate, rugged robust, simple and rapid than spectrometric method.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | HPLC Method; UV – Spectrophotometric;Drotaverine Hydrochloride; Mefenamic Acid; RP – HPLC Method; Olmesartan Medoxomil; Hydrochlorothiazide; |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ravindran C |
| Date Deposited: | 17 Aug 2017 08:00 |
| Last Modified: | 17 Aug 2017 08:00 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2672 |
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