Parasuraman, P (2012) Design, Synthesis, Characterization And Biological Evaluation Of Novel Flavone Derivatives: Molecular Docking Studies. Masters thesis, KMCH College of Pharmacy, Coimbatore.
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Abstract
In the past 60 years, antibiotics have been critical in the fight against infectious disease caused by bacteria and other microbes. However, disease-causing microbes that have become resistant to antibiotic drug therapy are an increasing public health problem. Another part of the problem is due to increasing use, and misuse, of existing antibiotics in human and veterinary medicine and in agriculture. Antimicrobial resistance is not a new problem but one that is becoming more dangerous; urgent and consolidated efforts are needed to avoid regressing to the pre-antibiotic era. Drug resistance is becoming more severe and many infections are no longer easily cured, leading to prolonged and expensive treatment and greater risk of death. Microbial development of resistance, as well as economic incentives, has resulted in research and development in the search for new antibiotics in order to maintain a pool of effective drugs at all times. While the development of resistant strains is inevitable, the slack ways that we administer and use antibiotics has greatly exacerbated the process (78). Among the various factors that have contributed to the current resurgence of malaria, growing resistance to anti-malarial drugs is perhaps the most important. The rising all-cause mortality rate among African children is attributable directly to malaria and specifically to the rapidly increasing resistance to anti-malarial drugs. Drug resistance is also emerging as a serious problem in the Indian subcontinent. The number of effective drugs available to treat malaria is small and the rate at which resistance is growing is outpacing the development of new anti-malarials. Nearly all the anti-malarials that are in use today were developed almost 30 years ago and, in general, the pharmaceutical companies, particularly the multinationals, have little interest in developing new cure despite the enormous need. Flavones have attracted continuing interest because of their varied biological activities namely anti-bacterial, anti-fungal, anti-Malarial, anti-viral, anti-oxidant, hepatoprotective, anti-inflammatory, anti-cancer, cardiovascular, anti-osteoporotic effects, anti-allergic, Anti-Alzheimer and anti-thrombotic activity.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Synthesis; Characterization; Biological Evaluation; Novel Flavone Derivatives; Molecular Docking Studies |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ravindran C |
| Date Deposited: | 17 Aug 2017 07:15 |
| Last Modified: | 12 Oct 2017 03:08 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2663 |
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