Sathishkumar, A (2021) Drug Design, Molecular Docking Studies, Microwave Assisted Synthesis and Characterization of Novel Schiff’s Bases of Dibenzosuberenone Derivatives as Anti-Histamine and Anti-Depressant. Masters thesis, College of Pharmacy, Madurai Medical College, Madurai.
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Abstract
The project work entitled “Drug Design, Molecular docking studies, Microwave assisted synthesis and Characterization of novel Schiff’s base of Dibenzosuberenone derivatives as antihistamine and anti-Depressant”. The methods proposed have not been reported till date. The above study comprises of the following steps: • Designed the Schiff's base of dibenzosuberenone and assessed ADME property by chemsketch, molinspiration, and swissADME software. • molecular docking studies were performed on the designed compounds • Optimized the method of synthesis for the proposed compounds. • Synthesized the dibenzosuberenone derivatives by using microwave irradiation technique. • The synthesized compounds were purified by recrystallization and identified by TLC. • Determined the physical properties such as solubility, melting point and Rf value. • Characterized the structure of synthesized compounds by • UV SPECTROSCOPY. • IR SPECTROSCOPY. • 1H NMR. • MASS. • The IR spectra showed the relevant functional group for all synthesized compounds. • The 1H NMR showed the relevant proton signals for all synthesized compounds. • The molecular mass was determined by MASS spectroscopy. A new series of novel Schiff base of Dibenzosuberenone derivatives have been prepared and characterized by spectral data. CONCLUSION: Efficient and environmentally benign methodologies for the synthesis of novel schiff’s base of Dibenzosuberenone derivatives using microwave irradiation has been reported. several advantages including percentage yield, reduced time and reduced pollution. So further development of the novel schiff’s base of dibenzosuberenone derivatives may be used to achieve the antihistamine and antidepressant activity in future.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 261915753 |
| Uncontrolled Keywords: | Drug Design, Molecular Docking Studies, Microwave Assisted Synthesis, Characterization, Novel Schiff’s Bases, Dibenzosuberenone Derivatives, Anti-Histamine, Anti-Depressant. |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Subramani R |
| Date Deposited: | 02 Nov 2022 18:01 |
| Last Modified: | 02 Nov 2022 18:01 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20934 |
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