Buvaneswari, P (2021) Design and Development of Pyridinyl Triazole Derivatives as Anticancer Agents. Masters thesis, C. L. Baid Metha College of Pharmacy, Chennai.
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Abstract
The present study was focused on developing the computational tools which helps in minimizing the process of drug discovery. • A set of 17 compounds were docked against the target EGFR tyrosine kinase PDB:1M17. • Among the 17 compounds, the top-ranked 5 compounds were synthesized using the conventional Methods. • Molecular docking studies of the active compounds revealed that these compounds might act via inhibition of EGFR tyrosine kinases (1M17). • All the synthesized compounds were evaluated for their physiochemical properties such as solubility, melting point analysis and Thin layer Chromatography. • Characterization of the synthesized compounds was done using Infrared spectroscopy, Mass spectroscopy. • The synthesized pyridine with triazole derivatives have been screened for their cytotoxicity in MCF-7 cell lines by MTT assay. • The findings indicated that the test compounds showed least to good activity. Altogether, these results show that the 5-aryl-3-phenylamino-1,2,4-triazole structure possesses fair anticancer activities and that derivative with a 3-amino phenol moiety (4e) seem to be the most promising one among other derivatives.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 261915003 |
| Uncontrolled Keywords: | Design, Development, Pyridinyl Triazole Derivatives, Anticancer Agents. |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Subramani R |
| Date Deposited: | 02 Nov 2022 16:50 |
| Last Modified: | 02 Nov 2022 18:03 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20904 |
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