Logeswaran, B (2021) Formulation and Evaluation of Levothyroxine Sodium Immediate Release Tablet. Masters thesis, Annai J.K.K. Sampoorani Ammal College of Pharmacy, Komarapalayam.
Full text not available from this repository.Abstract
Aim of the current research was to develop an Immediate Release Tablets formulation to enhance and ensure content uniformity and dissolution. Under the preformulation studies, the physical characterization of API, solubility study of API using media alkaline borate buffer (pH 10).) and drug excipient compatibility study was carried out and the result shows that all the physical characterization was found to be as per the monograph, the solubility of API is more soluble in alkaline borate buffer (pH 10) , than any other medium and there is no interaction in drug excipient compatibilitystudy. Five trial batches (trial 1-5) had been taken to formulate immediate release tablets by changing the concentration of excipients, to obtain an optimised formulation. The formulated granules were evaluated for precompression parameters such as bulk density, tapped density, Carr’s index, Hausner’s ratio and angle of repose and the result showed that the flow property was good. F5 exhibited a closer value for all in process parameters and it gives a good result. The formulated tablets were evaluated for post compression parameters such as hardness, thickness, friability, % of weight variation, disintegration time, dissolution, assay and content uniformity and it was found to be within the Pharmacopoeial limits. F5 exhibited a closer value for all in process parameters and it gives a good result. F5 formulation was subjected to stability study at accelerated conditions. The first month analysis of physical characters, assay and relative substance were found to be within Pharmacopoeial limits. It is concluded that the formulation Levothyroxine immediate release tablets was found to be a promising substitute for reference product by enhancing and ensuring content uniformity and dissolution. It is concluded that the formulation Levothyroxine immediate release tablets was found to be a promising substitute for reference product by enhancing and ensuring content uniformity and dissolution.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 261910807 |
| Uncontrolled Keywords: | Formulation, Evaluation, Levothyroxine Sodium, Immediate Release Tablet. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 12 Aug 2022 11:07 |
| Last Modified: | 12 Aug 2022 11:07 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20753 |
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