Abirami, A V (2019) Synthesis, Characterization & Biological Evaluation of Some Novel 1, 3, 4-Oxadiazole Derivatives. Masters thesis, Arulmigu Kalasalingam College of Pharmacy, Krishnankoil.
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Abstract
Substituted oxadiazole, 5-(2-hydroxyphenyl)-1, 3, 4-oxadiazole-2(3H)-thione was synthesized from salicylic acid. The titled oxadiazole derivatives were synthesized by making substitution at free N-(3H) position of 5-(2-hydroxyphenyl)-1, 3, 4-oxadiazole-2(3H)-thione through mannich condensation. Substituted oxadiazole, 5-(4-hydroxyphenyl)-1, 3, 4-oxadiazole-2(3H)-thione was synthesized from p-hydroxy benzoic acid. The titled oxadiazole derivatives were synthesized by making substitution at free N-(3H) position of 5-(4-hydroxyphenyl)-1, 3, 4-oxadiazole-2(3H)-thione through mannich condensation. The synthesized compounds were characterized by melting point and solubility and subjected to various analytical techniques like Thin Layer Chromatography, IR and NMR spectral studies. Synthesized compounds ODAZ 06, PDAZ 06, ODAZ 05, PDAZ 05, ODAZ 03, and PDAZ 03 compounds posses highly significant anti-convulsant activity. The synthesized compounds ODAZ 03, PDAZ 03, ODAZ 01, PDAZ 01 ODAZ 06, and PDAZ 06 possess significant anti-inflammatory activity at 90 mins. The synthesized compound ODAZ 03 possesses highly significant antinociceptive activity. The synthesized compounds Compound, ODAZ 04, PDAZ 04, ODAZ 03, PDAZ 03, ODAZ 02, PDAZ 02 posses significant anti-bacterial activity against both G(+ve) and G(-ve) organisms. The synthesized compounds Compound, ODAZ 03, PDAZ 03, ODAZ 04, PDAZ 04, ODAZ 05, PDAZ 05 posses significant anti-fungal activity against Candida albicans, Aspargillus nigar The synthesized compounds Compound, ODAZ,ODAZ 05, PDAZ 05, ODAZ 04, PDAZ 04, ODAZ 03, PDAZ 03 posses significant anthelmintic activity against pheritima posthuma
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 261715351 |
| Uncontrolled Keywords: | Synthesis, Characterization, Biological Evaluation, 1, 3, 4-Oxadiazole Derivatives |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 12 May 2022 05:55 |
| Last Modified: | 12 May 2022 05:55 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20022 |
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