Kathiravan, S (2020) In Silico, Synthesis and Mao-A Inhibitory Activity of Ketonic Mannich Bases of Isatin. Masters thesis, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore.
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Abstract
The present studyestablishes that computational tools help in minimizing the tedious process in drug discovery. Molinspiration was utilized for filtering the compounds and selecting the lead compounds. The binding energy obtained from docking study further confirmed the possibility of the affinity of the selected leads towards the enzyme MAO- A. Using the schemes various isatin derivatives were synthesized with good yield. Structure of the synthesized compounds were confirmed by Melting point, TLC, UV, IR, NMR and MASS spectra. Among the compounds screened for antidepressant activity CIS1 showed the highest activity. Thus, the present study depicts that the utilization of computer aided drug design is an effective tool in predicting the effectiveness of a series of isatin derivative compounds under study and thus can result in the design of potent antidepressant agents.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 261815102 |
| Uncontrolled Keywords: | Silico, Synthesis, Mao-A Inhibitory Activity, Ketonic Mannich Bases, Isatin |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 21 Apr 2022 05:47 |
| Last Modified: | 21 Apr 2022 05:47 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/19353 |
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