Divya, R (2023) Serum Creatinine Phosphokinase as an Prognostic Indicator in Acute Organophosphorous Poisoning. Masters thesis, Government Thiruvarur Medical College, Thiruvarur.
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Abstract
BACKGROUND: Organophosphorous compounds are commonly used pesticides and insecticides. In developing countries like India, suicidal deaths from organophosphorous poisoning is increasing day by day. Easily available laboratory investigations predicting toxicity could be a boon to the treating doctors in resource limited settings. One such important predictor which has been quoted in various articles is serum creatine phosphokinase. CK is an indicator of muscle fibre necrosis and is proposed to indicate the impending respiratory failure and complications. Hence serial monitoring of CK levels would help us in assessing the outcome of the patients. This would also help us in deciding the rapid and timely interventions necessary to avoid death due to organophosphorous compound poisoning AIM OF THE STUDY: Aim of the study is to use Creatine kinase as a prognostic indicator in acute organophosphorous poisoning. METHODS: After obtaining the informed consent details of history and clinical examination were recorded. Peradeniya OP poisoning scale was applied to all study subjects and the severity of OP poisoning was graded as mild, moderate, severe. In all study subjects blood was collected on admission, day 3, for estimation of serum creatine phosphokinase. Other routine investigations were done. Statistical analysis were made. RESULTS: Out of 100 patients, the study population comprised of 34% females and 66% males. The mean age of study population was37.7 years and Standard deviation of 13.The predominant age group of the study population were in the age group of 31-40 years. The most common OP compound ingested was chlorpyriphos. The mortality rate in our study is 14 %. The severity of opc poisoning correlates with creatine phosphokinase with statistically significant values. CONCLUSION: Raised serum CK levels significantly correlated with initial clinical severity by POP scoring, increasing atropine requirement, hospital stay duration, complications . Hence, we have concluded that levels of Serum CK can be used as parameter for assessing the severity and Outcome of Acute OPC poisoning.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | REG.NO: 200120109002 |
| Uncontrolled Keywords: | Serum Creatinine Phosphokinase, Prognostic Indicator, Acute Organophosphorous Poisoning. |
| Subjects: | MEDICAL > General Medicine > MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 17 Aug 2021 14:55 |
| Last Modified: | 27 Apr 2024 06:49 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/17991 |
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