Amit Kumar, Dutta (2008) Does Anti Saccharomyces Cervisiae Antibody (ASCA) distinguish Crohn's Disease from Intestinal Tuberculosis - A Pilot Study. Masters thesis, Christian Medical College, Vellore.
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Abstract
INTRODUCTION : Crohn’s disease (CD) is now diagnosed with increasing frequency at many centres in India. Intestinal tuberculosis (ITB) frequently encountered in our country is difficult to distinguish from CD as both diseases have similar radiological, endoscopic and histologic features. Differentiation of CD from ITB is important both for planning treatment and assessing prognosis. Studies from the west have shown that there is a high prevalence of ASCA in Crohn’s disease. They have used this to differentiate Crohn’s disease from ulcerative colitis in patients with indeterminate inflammatory bowel disease. If the prevalence of ASCA is low in intestinal tuberculosis, it is possible that ASCA can be used as serological marker to help differentiate Crohn’s disease from intestinal tuberculosis. Anti Saccharomyces cerevisiae Antibodies (ASCA) are directed against cell wall oligo mannosidic epitopes of S.cerevisiae. The test is commercially available and is an ELISA based test which can be done in most laboratories. Therefore the aim of the present study was to assess prevalence of ASCA in CD and ITB and evaluate the role of this serological marker in differentiating these 2 diseases. AIMS : To prospectively study the prevalence of ASCA among patients with Crohn’s disease and intestinal tuberculosis and assess the ability of ASCA to differentiate Crohn’s disease from Intestinal tuberculosis and To assess the ability of clinical presentation, radiology, endoscopy and histopathology to differentiate Crohn’s disease from intestinal tuberculosis CONCLUSIONS : Differentiating CD from ITB continues to be a challenging problem. Our study confirms the results of 2 other studies from India that ASCA does not help to differentiate CD from ITB 85, 86. Presently, a combination of clinical features, endoscopy, histology, radiology and response to treatment continues to be the mantra to differentiate these two conditions. We need to continue to strive to develop new tests to help clinicians differentiate the two conditions.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Anti Saccharomyces Cervisiae Antibody (ASCA) ; Crohn's Disease ; Intestinal Tuberculosis ; Pilot Study. |
| Subjects: | MEDICAL > Gastroenterology |
| Depositing User: | Kambaraman B |
| Date Deposited: | 14 Jul 2017 03:12 |
| Last Modified: | 14 Jul 2017 03:12 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1621 |
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