Arun, R (2011) Seroprevalence of Human Cytomegalovirus among Voluntary Blood Donors in Chennai. Masters thesis, The Tamil Nadu Dr. M.G.R. Medical University, Chennai.
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Abstract
Blood Transfusion is a life saving modality. The transfusion of blood and blood products is much safer than ever before but still a long way from achieving universal access to safe blood transfusion. A Transfusion Transmitted Infection (TTI) is any potential pathogen that can be transmitted in donated blood through a transfusion to a recipient. The magnitude of the problem of transfusion transmitted diseases varies from country to country depending on disease prevalence. Various measures are taken in a country to make blood transfusion therapy safe for the respective population. There is a long list of viruses, parasites and bacteria and recently prion diseases, which can be transmitted through blood transfusion. Majority of the problems are due to the prevalence of asymptomatic carriers in the society as well as blood donations during window period of infections. Viral infections assume a great importance in transfusion associated mortality and morbidity in patients. Important transfusion transmitted viruses are HIV, HBV, HCV, HTLV, Parvo virus B-19 and cytomegalovirus. The seroprevalence of IgG anti-CMV antibody among voluntary blood donors in Chennai is 92.8% (167 out of 180). The high prevalence indicates the endemicity of infection, and this perhaps is related to socio-economic and environmental factor. • None of the IgG CMV seronegative donors were found to contain CMV DNA by RT-PCR. However, in order to rule out CMV infected donors in window period, it is imperative to confirm all cases of seronegative donors by RT-PCR. • IgG seropositivity is found to be significantly high in lower socioeconomic status and female population. • Age, educational qualification, marital status and blood group do not have any correlation with IgG CMV seropositivity. • None of the donors were found to be IgM anti-CMV antibody positive. Considering the cost being high and IgM antibody positive donors seldom found, screening for IgM anti-CMV antibody may be practiced only for high risk recipients. Seronegative blood component is utmost essential for high risk patients. However, if seronegative components are not available, IgG anti-CMV seropositive leukoreduced components may be used. • Due to dearth of seronegative donors in developing countries like India, latest techniques like pathogen inactivation may be made practically available in few centers catering high risk groups.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Seroprevalence ; Human Cytomegalovirus ; Voluntary Blood Donors ; Chennai |
| Subjects: | MEDICAL > Immunohaematology Blood Transfusion |
| Depositing User: | Kambaraman B |
| Date Deposited: | 21 Jun 2017 06:40 |
| Last Modified: | 16 Jun 2019 02:15 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/154 |
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