Sasikumar, K (2014) Design Synthesis, Characterization and Invitro Biological Evaluation of Novel Series of 1- Substituted Isatin Derivatives by Mannich Reaction. Masters thesis, College of Pharmacy, Madurai Medical College, Madurai.
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Abstract
The Medicinal chemistry is the Branch of Science, which study about the synthesis, SAR, QSAR, Molecular biology, structure modification for optimization of their activity and Biological activity of medicinal compounds. Drug synthesized from natural source by Extraction and isolated the lead compounds. Then it is involved in the semi synthetic, synthetic process and retro synthetic analysis. The purity of the synthesised compounds were analysed by thin layer chromatography. The structure of the synthesised compound has been elucidated by infra red ,nuclear magnetic resonance,mass spectroscopy. The compound S5,S7,S8 shown potent antibacterial activity against salmonella typh.i the compound S7,S10 shown best anti bacterial activity against staphylococcus aureas both are compared to standard amikacin. The new data might be helpful in the future development of isatin analogue as novel broad spectrum antibacterial agent. The compound S4,S7,S8 Shown good anti oxidant properties it has identified by the assay of hydrogen peroxide method. The anti cancer activity of the synthesised compounds were screened by using MTT assay in cervical cancer cell line, from this result compound S8 having 67%cell viability. so the compound S8 shown significantly less cytotoxic activity. Ultimately i would like to deliver the compound S8 (1-[1H-benzimidazole-1-yl methyl]-1H-indole-2, 3 –dione)having three activities like ant oxidant activity, anti bacterial activity and cytotoxic activicty, in future compound S8 should be modified by chemical reaction when it gives potent and effective molecule.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Design Synthesis; Characterization; Invitro Biological Evaluation; Novel Series; Substituted Isatin Derivatives; Mannich Reaction |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ravindran C |
| Date Deposited: | 12 Jul 2017 06:28 |
| Last Modified: | 12 Oct 2017 03:02 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1520 |
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