Venniladevi, A (2020) A Study to Evaluate the Associated Systemic Risk Factors in Type 2 Diabetes Mellitus patients with Clinically Significant Macular Edema. Masters thesis, Government Mohan Kumaramangalam Medical College, Salem.
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Abstract
INTRODUCTION: Clinically significant macular edema is one of the major causes of preventable blindness across the world in both developing countries like INDIA and developed countries. Clinically significant macular edema is one of the major causes of legal blindness mainly in working age group population. As the prevalence of diabetes has already reached epidemic proportions due to increase in aging population and sedentary lifestyle, the early identification of the risk factors for diabetic macular oedema and early prevention of the same becomes essential to prevent vision loss. AIM OF THE STUDY: To evaluate the association of systemic risk factors with clinically significant macular edema in type 2 diabetes mellitus patients. STUDY DESIGN: A hospital based cross sectional study conducted between October 2017 and September 2019. METHODOLOGY: All patients included in the study were subjected to complete ophthalmologic examination by assessing the visual acuity with Snellen chart, slit lamp examination, Fundus examination with direct ophthalmoscope, indirect ophthalmoscope, and slit lamp bio microscopy with +90D lens. Clinically Significant Macular Edema and Diabetic Retinopathy were graded as per Early Treatment Diabetic Retinopathy Study criteria. The detailed history of age of the patient, duration of diabetes mellitus, treatment history were recorded. The body mass index (BMI), abdominal circumference (AC), blood pressure(BP), total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL), triglycerides (TG), Hemoglobin (Hb), Fasting Blood Glucose(FBG), Post prandial Blood Sugar (PPBS), HbA1c, serumcreatinine and proteinuria were collected. To find the significance in categorical data Chi-square test and fischer exact test were used. P value of < 0.05 is considered as statistically significant. RESULTS: On analysis of multiple risk factors focal maculopathy had significant association with body mass index with P value being 0.044.Diffuse maculopathy had significant association with HbA1c with p-value being 0.026. CONCLUSION: In the analysis of systemic risk factors, a significant correlation was found to exists between abnormal BMI and focal maculopathy and diffuse maculopathy was associated with increased levels of HbA1c. Patients with more number of risk factors developed Clinically Significant Macular Edema within a period of 5 years, even with adequate glycaemic control.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 221713602 |
| Uncontrolled Keywords: | Clinically significant macular edema, Systemic risk factors, Diabetes mellitus. |
| Subjects: | MEDICAL > Ophthalmology |
| Depositing User: | Subramani R |
| Date Deposited: | 14 Feb 2021 13:39 |
| Last Modified: | 14 Feb 2021 13:39 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/14188 |
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