Durai Arasan, R (2020) A Study of Correlation of Heart Rate Variability and Serum Uric Acid with Blood Pressure in Normotensives and Stage 1 Hypertensives. Masters thesis, Coimbatore Medical College, Coimbatore.
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Abstract
INTRODUCTION: American Heart Association (AHA) has defined hypertension as a systolic pressure of ≥ 130 mm Hg and/or a diastolic pressure of ≥ 80 mm Hg. Hypertension has ill effects on almost all organ systems of the body and has multiple risk factors among which autonomic nervous system balance and serum uric acid are studied here. Autonomic nervous system has two components – sympathetic and parasympathetic. Influence of autonomic nervous system over the heart can be studied by Heart Rate Variability (HRV). Uric acid is the end product of purine metabolism. AIM AND OBJECTIVES: To compare and correlate the HRV parameters and serum uric acid values with blood pressure in normotensive and stage 1 hypertensive subjects. METERIALS AND METHODS: A total of 120 volunteered subjects (60 normotensives and 60 newly diagnosed stage 1 hypertensives) were selected from non-communicable diseases OPD. They were subjected to HRV analysis and serum uric acid analysis. The results were analysed using SPSS software and unpaired t-test and correlation were done for the mean values of HRV analysis and serum uric acid levels from normotensives and hypertensives. RESULTS: Study result shows that significantly increased levels of Low Frequency [LF] values, LF normalized unit [LF nu] and Low frequency high frequency ratio [LF/HF] are seen in hypertensives when compared with normotensives. This shows increased sympathetic activity in hypertensives. HFnu values are decreased in hypertensives when compared with normotensives, signifying decreased parasympathetic activity in hypertensives. Mean serum uric acid levels were increased in hypertensives when compared with normotensives. DISCUSSION: Hypertensives had increased sympathetic activity and decreased parasympathetic activity when compared with normotensives. The study showed as the mean blood pressure increased the sympathetic activity increased and parasympathetic activity decreased. Thus hypertensives had reduced HRV due to impaired autonomic balance. The study also showed that as the mean blood pressure increased, serum uric acid levels also increased. CONCLUSION: Hypertensives have autonomic system imbalance and increased serum uric acid levels. Hence, HRV analysis and uric acid estimation should become part of routine investigation in hypertensives and treatment should be done accordingly.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 201715251 |
| Uncontrolled Keywords: | Hypertension, autonomic nervous system, Heart Rate Variability, serum uric acid. |
| Subjects: | MEDICAL > Physiology |
| Depositing User: | Subramani R |
| Date Deposited: | 30 Jan 2021 17:02 |
| Last Modified: | 01 Mar 2021 02:53 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/13495 |
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