Mithun Abraham Prakash, (2020) To assess the ovarian reserve in young women with Systemic Lupus Erythematosus (SLE) using Anti Mullerian Hormone, presenting to a tertiary care hospital in South India. Masters thesis, Christian Medical College, Vellore.
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Abstract
BACKGROUND: Systemic lupus erythematosus is one of the most common rheumatologic diseases, with a high incidence among women in the reproductive age group. It has manifestations in virtually every organ system in the body, including the reproductive system. Both the disease process as well as the treatment can affect the ovarian function and reproductive outcomes of patients. We aim to study the impact of SLE and its treatment on the ovarian function. OBJECTIVES: Primary Objective: To assess the ovarian reserve in treatment naive SLE patients using serum Anti mullerian hormone levels. Secondary Objective: 1. To identify factors contributing to the ovarian dysfunction in these patients. 2. To assess the impact of treatment on the ovarian reserve in SLE patients on follow up after therapy 3. To assess the quality of life using the SLEQoL questionnaire. 4. To assess menstrual health using a modified MDOT (menstrual disorders in teenagers) questionnaire. METHODS: This was a prospective cohort study recruiting women satisfying the SLICC criteria for Systemic Lupus Erythematosus. Patients who were included in the study included treatment naïve patients (those who had not received any treatment, patients whose treatment records were not available and those who had not been adequately treated in accordance to current guidelines) Data obtained from the patient included demographic data, data related to the disease process and symptoms to assess their disease severity, and menstrual history using a modified MDOT (menstrual disorders in teenagers) questionnaire and quality of life using SLE QoL questionnaire. A blood sample was be taken from them at the beginning of the study to check their AMH levels. RESULTS: The study showed that patients with Systemic Lupus Erythematosus had decreased ovarian reserve in the form of lower Anti Mullerian hormone levels. It was also seen that patients with increased disease activity had lower AMH levels as compared to patients with lower disease activity. It was also seen that patients with urinary casts, hematuria, pyuria, proteinuria, alopecia, pleuritis, pericarditis, low complement levels and elevated ds DNA levels all had lower Anti Mullerian hormone levels as opposed to patients who didn’t have the same and the results were significant for the same.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 201711460 |
| Uncontrolled Keywords: | Anti Mullerian hormone, Systemic Lupus Erythematosus, Ovarian reserve, Menstrual function, Quality of life. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 28 Jan 2021 19:04 |
| Last Modified: | 31 Jan 2021 04:08 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/13350 |
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