Yoganandhini, C (2017) Comparison of Efficacy and Safety of Topical 5% Dapsone Vs Topical 5% Benzoyl Peroxide in Mild to Moderate Acne Vulgaris. Masters thesis, Stanley Medical College, Chennai.
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Abstract
BACKGROUND: Acne vulgaris is a self-limiting inflammatory disease of pilosebaceous units seen predominantly in adolescents, characterised by seborrhoea & pleomorphic lesions like open and closed comedones, erythematous papules, pustules, nodules, cysts and in many cases scarring will ensuewhich can be either mild or severe, depending upon the degree of inflammation. The condition is most common between 12-25 years. AIM AND OBJECTIVES: To compare the efficacy and safety of topical 5% Dapsone Vs topical 5% Benzoyl peroxide in mild to moderate acne vulgaris. TYPE OF STUDY: Open labelled randomized comparative study. MATERIALS AND METHODS: The patients with mild to moderate grade acne vulgaris will be randomly divided into 2 groups of 20 patients each, after explaining the study procedure and obtaining consent. Benzoyl peroxide 5% gel twice daily for 12 weeks - Group A. Dapsone 5% gel twice daily for 12 weeks – Group B. The patients will be followed up on 2nd, 4th, 8th and 12 weeks. Post treatment follow up done at end of 1st, 2nd and 3rd months. RESULTS: In our study, out of 30 patients in topical benzoyl peroxide group, marked improvement was seen in 9(30%) and moderate improvement was seen in 11(36.67%). In topical dapsone group, marked improvement was seen in 3(10%) and moderate improvement was seen in 6(20%). 13.3% of study participants in benzoyl peroxide group and 53.3% in dapsone group showed no improvement in the grades of lesion. CONCLUSION: During the follow up period, response was better with decrease in proportion of grade 2 lesions being higher in group A than in group B patients. Overall improvement in grades of the lesion was more in group A compared to group B. In our study, dapsone response was seen with inflammatory lesions whereas benzoyl peroxide effect was seen with both inflammatory and non inflammatory lesions.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.201430054 |
| Uncontrolled Keywords: | Acne vulgaris, seborrhoea, benzoyl peroxide, dapsone. |
| Subjects: | MEDICAL > Dermatology Venereology and Leprosy |
| Depositing User: | Subramani R |
| Date Deposited: | 22 Jul 2020 15:08 |
| Last Modified: | 22 Jul 2020 15:08 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/12637 |
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