Vidhyalakshmi, C K (2017) APRI scoring as a predictor of Hepatic Fibrosis in patients with Chronic Hepatitis B and / or C Infection in comparison with Fibroscan. Masters thesis, Madras Medical College, Chennai.
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Abstract
INTRODUCTION: Chronic liver disease is a global issue leading on to cirrhosis and hepatocellular carcinoma. Liver biopsy even though a standard criterion for the determination of fibrosis, is an invasive approach, thus, noninvasive simple laboratory markers were used to predict fibrosis in patients with chronic hepatitis B / and C infection. AIMS AND OBJECTIVES: Comparison of the accuracy between Aspartate aminotransferase (AST) to platelet count ratio index (APRI) value to Fibroscan to predict fibrosis of liver in patients with chronic Hepatitis B / and C infection. MATERIALS AND METHODS: An observational study was conducted among 100 patients attending Hepatology OP department with inclusion criteria – chronic Hepatitis B /and C infection in the age group of 18 – 60 years and exclusion criteria being coinfection with HIV, chronic renal failure, thrombocytopenia of < 75,000 cells/ul, other etiologies of chronic liver disease. Demographic data and medical history were collected from the patient and were subjected to platelet count estimation, liver function tests and Fibroscan. RESULTS: From the study, it was evidenced that the Aspartate aminotransferase (AST) to platelet count ratio index (APRI) value was correlating with Fibroscan value. Out of 72 patients with normal liver architecture identified on fibroscan, 68 patients correlate well with APRI score. Similarly, out of 14 patients with fibrosis detected on Fibroscan, 9 patients correlate well with APRI score. CONCLUSION: It was concluded from our study that, ASPARTATE AMINOTRANSFERASE (AST) TO PLATELET COUNT RATIO INDEX (APRI) value was correlating with FIBROSCAN value with sensitivity and specificity around 88 -90%.Thus, it could be used as a non-invasive tool to detect fibrosis in patients with chronic Hepatitis B / and C infection.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | Reg.No.201411023 |
| Uncontrolled Keywords: | Aspartate Aminotransferase (AST) to Platelet Count Ratio Index (APRI) Value, Fibroscan, Chronic Hepatitis B Infection, Cirrhosis/Fibrosis. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 12 Mar 2020 10:32 |
| Last Modified: | 12 Mar 2020 10:32 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/12223 |
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