Govish Kamal, A (2019) Comparison of Intrathecal Nalbuphine Vs Fentanyl Added to 0.5% Hyperbaric Bupivacaine for Perioperative Anaesthesia and Perioperative / Post Operative Analgesia in Hernioplasty. Masters thesis, Tirunelveli Medical College, Tirunelveli.
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Abstract
BACKGROUND: Various adjuvants are added to the local anaesthetics intrathecally, to prolongate the duration of anaesthesia. Among the adjuvants the most commonly preferred are the opioids. Various opioids have been used intrathecally like morphine, fentanyl, buprenorphine and nalbuphine to fasten the onset and prolong the duration of sensory and motor blockade. This study is designed to compare the effects of intrathecal nalbuphine with fentanyl as adjuvants to bupivacaine in hernioplasty. AIM OF THE STUDY: The aim of the study was to Compare intrathecal nalbuphine vs fentanyl added to 0.5% hyperbaric bupivacaine for perioperative anaesthesia and postoperative analgesia in patients undergoing hernioplasty. MATERIAL & METHODS: 120 patients undergoing elective hernioplasty surgery were randomly assigned into three groups of 40 patients each. They received 3ml of 0.5% hyperbaric bupivacaine mixed with either 0.5ml of nalbuphine (500μg) or 0.5ml of fentanyl (25μg). Onset of sensory and motor block, duration of sensory block and motor block, highest sensory level, time to reach highest sensory level, two segment regression of sensory block and duration of analgesia were studied. RESULTS: The onset of sensory and motor blockade, time to reach highest sensory level was prolonged in the nalbuphine group. The duration of sensory blockade, two segment regression of sensory block, and duration of analgesia was prolonged in the nalbuphine group than fentanyl group. The number of patients to reach highest sensory level T2-T4 was more in nalbuphine group. CONCLUSION: Comparing between Intrathecal Nalbuphine and Fentanyl concludes that: Intrathecal Nalbuphine may be a good alternative to Fentanyl in surgeries like hernioplasty and in below umbilical surgeries which provides a prolonged sensory and motor blockade, and prolonged duration of analgesia without any adverse effects.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Intrathecal, Nalbuphine, Fentanyl, Opioids. |
| Subjects: | MEDICAL > Anaesthesiology |
| Depositing User: | Subramani R |
| Date Deposited: | 19 Aug 2019 01:07 |
| Last Modified: | 19 Aug 2019 01:07 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/11025 |
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