Shams Eldein Ahmed Ali, Dangoal (2018) TPGS Stabilized Silymarin Proliposome: Improve Phisico Chemical Properties and Hepatoprotective Activity. Masters thesis, Nandha College of Pharmacy, Erode.
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Abstract
Silymarin proliposome was successfully prepared by film deposition method. This method of manufacturing was found to be simple, did not require specialized equipments and has scale – up feasibility. The proliposome was converted into dry powder by lyophilization in order to increase its stability. From the reports, the particle size and zeta potential values were measured immediately after preparation of proliposome. The particle size of the lyophilized proliposome is homogenous in size and size distribution. All the formulation showed lower particle sizes. Zeta potential is an indication of the stability of the proliposomes. The Zeta potential of formulation was around ± 20 mV. The zeta potential of best formulation (SF2) indicating good quality. In FT-IR study proliposome showed the characteristic peeks due to pure silymarin without any markable change in their position, indicating no chemical interaction between silymarin and polymers. In-vitro dissolution studies indicated that the dissolution rate of the drug from the lyophilized proliposomes is significantly higher than that of the pure drug. This study indicated higher drug diffusion from proliposome, possibly due to higher increases in saturation solubility and dissolution rate than plain drug. The in-vitro permeability results show that the drug diffusion across the nitrocellulose membrane from proliposome is significantly higher than the plain drug. From the previous reports the hepatotoxicity play a critical role in pathogenesis of CIS induced hepato toxicity. Pretreatment with SF2 significantly attenuated CIS-induced functional liver compared to silymarin. One possible reason of SF2-mediated preservation is that, before CIS administration, pretreatment with SF2 could permit inception of free radicals produced by CIS prior to reaching DNA and causing damage. The study provides strong evidence for the use of the SF2 has hepato protective activity against CIS induced damage in liver. Therefore, SF2 could be an encouraging chemoprotective agent to approach CISmediated toxicity. These observations lead us to the conclusion that proliposome seems to be a promising drug delivery system, which can provide an effective and practical solution to the problem of formulating drugs with low aqueous solubility, poor systemic bioavailability and its hepatoprotective activity.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Rreg.No. 261610451 |
| Uncontrolled Keywords: | TPGS Stabilized Silymarin Proliposome ; Improve Phisico Chemical Properties ; Hepatoprotective Activity. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Subramani R |
| Date Deposited: | 25 Jun 2019 03:49 |
| Last Modified: | 25 Jun 2019 03:49 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10612 |
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