Senthil Kumar, E (2016) Comparative Analysis of Apache-II Score and Sofa Score as Predictors of Mortality in Patients admitted with Sepsis and Multi Organ Dysfunction Syndrome. Masters thesis, Madras Medical College, Chennai.
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Abstract
BACKGROUND: Sepsis with multi organ dysfunction is a major cause of mortality. This study is aimed at comparing two of the prognostication scoring systems namely APACHE 2 and SOFA scores in Sepsis – MODS. MATERIALS AND METHODS: This study included 60 patients and was conducted for 6 months from April 2015. APACHE II and SOFA scores were calculated for the patients admitted with sepsis – MODS and 30 day mortality was assessed. The study included 31 males and 29 females. Among the 60 patients 22 died within 30 days (mortality percentage 36.6 %). The APACHE 2, SOFA 1, SOFA 3 and mean SOFA scores had significant correlation with mortality. A higher value of APACHE 2 and SOFA scores were associated with higher mortality. Progressive increase in SOFA scores were noted in non survivor groups. Apart from these scores, some of their component variables namely the heart rate, respiratory rate, serum sodium, serum creatinine, Glasgow coma scale and serum bilirubin were also noted to have significant (p < 0.05) correlation with mortality in sepsis – MODS. RESULTS: Both APACHE 2 and SOFA scores are useful predictors of mortality in patients with sepsis – MODS. Rising SOFA scores on subsequent days is associated with higher mortality. Heart rate, respiratory rate, serum sodium, serum creatinine, Glasgow coma scale and serum bilirubin were also noted to have independent correlation with mortality in these patients
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.201311022 |
| Uncontrolled Keywords: | Sepsis ; multi organ dysfunction syndrome ; SOFA score ; APACHE 2 score ; prognostication score ; septic shock ; systemic inflammatory response syndrome. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 06 Feb 2019 07:59 |
| Last Modified: | 06 Feb 2019 07:59 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10519 |
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