Mohamed Iliyas, A (2016) Glycemic Profile of Patients on Hydroxychloroquine. Masters thesis, Madras Medical College, Chennai.
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Abstract
BACKGROUND: Hypoglycemia is a known adverse effect of treatment with Hydroxychloroquine. Diabetes Mellitus is the leading metabolic disease world wide. The higher cost of the existing oral hypoglycemic agents have led to the development of a number of newer oral hypoglycemic agents. Hydroxy chloroquine, an old drug which is comparatively cheaper can be considered for the treatment of diabetes, if it is found to be effective. OBJECTIVE: To compare the efficacy of Hydroxychloroquine in decreasing the blood glucose in patients suffering from rheumatic diseases. METHODS: 100 patients newly diagnosed with a rheumatological disease were selected of which 70 had Rheumatoid arthritis and 30 had Systemic lupus erythematosus. Baseline HbA1c, FBS and PPBS were measured and compared after 3 months of treatment with Hydroxychloroquine at a dose of 200 mg twice daily. Efficacy is assessed by the changes in HbA1c, Fasting and Post prandial Blood Glucose after 3 months. RESULTS: Out of the 100 patients chosen for the study, 30 were Diabetic, 30 were Impaired glucose tolerant and 40 were Normal glucose tolerant at the beginning of the study. At the end of 3 months mean decrease in HbA1c was 0.362, 0.29 and 0.29% in Diabetes, Impaired glucose tolerance and Normal glucose tolerance patients respectively. All of them had a p value of 0.001 and was highly significant. Mean decrease in Fasting blood sugar was 10.42 mg/dl, 8.44 and 8.44 mg/dl in Diabetes, Impaired glucose tolerance and Normal glucose tolerance patients respectively. All of them had a p value of 0.001 and was highly significant. Mean decrease in Postprandial blood sugar was 6.2 mg/dl, 3.97 and 3.97 mg/dl in Diabetes, Impaired glucose tolerance and Normal glucose tolerance patients respectively. The p value in Diabetes, patients, Impaired glucose tolerant and Normal glucose tolerant patients were 0.148, 0.127 and 0.127 respectively and were not significant. CONCLUSION: Hydroxychloroquine has greater effect in decreasing blood glucose in Diabetes Mellitus compared to patients with Impaired and Normal glucose tolerance.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.201311023 |
| Uncontrolled Keywords: | Diabetes Mellitus ; Hydroxychloroquine ; Oral hypoglycemic agent ; HbA1c ; Fasting blood glucose ; Rheumatoid arthritis ; Systemic lupus erythematosus. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 06 Feb 2019 07:48 |
| Last Modified: | 06 Feb 2019 07:48 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10518 |
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