Rajalakshmi, M (2013) Preclinical and Clinical Study on Kalanjaga Padai. Masters thesis, National Institute of Siddha, Chennai.
Full text not available from this repository.Abstract
The disease Kalanjagapadai was taken for the clinical study with Soolaikku perumarunthu chooranam as internal medicine and Viranagalukku ennai as external application. For the clinical study, 40 cases were selected based approved protocol. The study is conducted after the drug being screened by the Screening committee and the trial is also approved by the Institutional Ethical Committee (IEC). Animal studies are carried out after obtaining approval from the Institutional Animal Ethical Committee (IAEC). Hence the study is safely executed on human volunteers and there was no adverse drug reactions noted during the study period. Out of the 40 cases, 20 cases were treated in IPD and remaining 20 cases were treated in OPD of Ayothidoss Pandithar Hospital of National Institute of Siddha, Chennai-47. The detailed study on Kalanjagapadai with reference to its etiology, pathogenesis, investigations, clinical features, diagnosis and treatment with trial drugs was done. Among the 20 IPD, patients 10 patients were taught Yogam therapy along with the above said internal and external medicines and the remaining 10 IPD patients received only internal and external medicine without any Yogam therapy being taught to them. The patients who received Yogam therapy along with their medications responded well since the Yogam therapy is mainly aimed to reduce the stress in the affected individual which plays a vital role in relapse of this disease. The results were found to be encouraging. Among the 40 cases treated, 55% cases had shown Good improvement, 25% cases had shown Moderate improvement, 20% had shown Poor improvement. CONCLUSION: The present clinical study confirms the efficacy of the trial drugs by reducing the clinical signs and symptoms like itching, scaling and erythema. Clinical study results found to be Good in 55% cases, Moderate in 25% cases, Poor in 20% cases. Yogam treatment along with internal and external medication is found to be more effective in the control and prevention of the disease. The subjects affected by psoriasis are most commonly affected by stress and social stigma. When these affected community get a good improvement with this trial drug and Yogam it would be a great releif for the suffering people. The Clinical trial conducted in selected patients was satisfactory and the results were encouraging. However a study with large number of patients is required to find out the ideal dose response. In this study, no untoward and adverse reactions were reported and regarding toxicological studies in animal models showed no abnormalities. Hence it is concluded that the trial drugs are clinically safe. The cost of the trial medicines are Low. These drugs are easily available and the dosage is also convenient.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Kalanjaga Padai ; Psoriasis ; Preclinical and Clinical Study. |
| Subjects: | AYUSH > Sirappu Maruthuvam |
| Depositing User: | Subramani R |
| Date Deposited: | 07 Jan 2019 03:23 |
| Last Modified: | 08 Jan 2019 14:18 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10354 |
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