Saranya, S (2015) Comparitive evaluation of clinical and radiological parameters of intrabony defects treated with simvastatin loaded collagen membrane / collagen membrane alone: 12 months randomized controlled clinical study. Masters thesis, J.K.K. Nataraja Dental College and Hospital, Komarapalayam.
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Abstract
AIM OF THE STUDY: Periodontitis is an immuno inflammatory disease of supporting tissues of the teeth, caused by specific microorganisms resulting in the progressive destruction of periodontal ligament, alveolar bone with pocket formation. The aim of the study is to evaluate the regenerative potential of simvastatin loaded on collagen membrane compared with collagen membrane alone in intrabony defects both clinically and radio graphically during 6, 12 months post-operative period. MATERIALS AND METHODS: The study population comprised of 10 patients and a total of 20 intrabony defects were divided into two group. GROUP1 were treated with simvastatin loaded collagen membrane, GROUP 2- collagen membrane alone. Plaque index (PI), Ginigval index (GI), oral hygiene index – simplified(OHI –S), probing pocket depth (PPD), clinical attachment level (CAL) were measured at baseline, 6 monthsand 12 months. RESULTS: The mean plaque index score at baseline was 1.99±0.260, 1.00±0.211 and 0.63±0.226 at 6 and12months post-operative period. The mean oral hygiene index –simplified score at baseline was 1.59±0.074, 0.69±0.074 and 0.044±0.052 at 6 and 12 months post – operative period. The mean gingival index score at baseline was 2.14±0.386, 1.37±0.46 and 1.32±0.238 at 6 12 months post-operative period. In group1, at baseline the mean probing pocket depth was 7.30±0.483, 3.60±0.516 and 3.25±0.483 at at 6 and12 months post-operative period. In group 2, at baseline it was 7.40±0.516, 4.6±0.516 and 4.4±0.516 at 6 and 12 months post –operative period. In group 1, at baseline the mean clinical attachment level was 7.4±0.527, 3.70±0.483 and 3.71±0.432 at 6 and 12 months postoperative period. In group 2, at baseline it was 7.50±0.527, 4.50±0.527 and 4.4±0.517 at 6 and 12 months. In group 1, at baseline the mean defect was 7.34±0.793 and the bone fill measured was 6.15±0.622 at 6 months and 5.74±0.381 at 12 months post – operative period. In group2, at baseline it was 7.13±0.868, and the measured bone fill was 6.09±0.568 at 6 months and 5.67±0.381 at 12 months. CONCLUSION: Both Simvastatin and collagen membrane yielded favorable clinical results in periodontal intrabony defects. Probing pocket depth and gain in attachment level were significant in both the groups when compared to pre-operative level. But probing pocket depth and clinical attachment level gain was greater in simvastatin with a statistically significant p- value of <0.001 than the collagen membrane alone at 6 and 12 months post operatively. Both the groups exhibited significant amount of bone fill than the pre-operative levels and the mean bone fill was higher in simvastatin treated group. But there is no statistical significance in between the two groups at 6 and 12 months post-operative period.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Simvastatin loaded collagen membrane ; intrabony defects. |
| Subjects: | DENTAL > Periodontology |
| Depositing User: | Subramani R |
| Date Deposited: | 29 Oct 2018 03:37 |
| Last Modified: | 29 Oct 2018 03:37 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10020 |
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