Ravanth Kumar, C (2013) Evaluation of the effects of Orthodontic Tooth Movement on the Levels of Interleukin - 10 in Gingival Crevicular Fluid. Masters thesis, Ragas Dental College and Hospital, Chennai.
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Abstract
When orthodontic forces are applied to a tooth, they are transmitted to the periodontal ligament (PDL) and adjacent alveolar bone. These forces, in turn, initiate a complex cascade of events that result in the remodeling of the surrounding bone and eventual movement of the tooth2. While the sequence of events at the tissue and cellular levels of bone remodeling is well described, there remains a lack of comprehensive understanding in the coordination of biochemical events at the molecular level. While there are numerous interconnected systems in place that control the levels of mature osteoclasts and osteoblasts active during bone remodeling, one predominate pathway uses the cytokine family interleukin -10 ( IL -10) as a signal transducer . Most importantly, IL - 10 plays a critical role in the differentiation of both osteoclasts and osteoblasts. Osteoclasts are derived from hematopoietic precursors in the bone marrow, whereas osteoblasts are mesenchymal in origin5. Regardless of the cell’s origin, however, IL-10 type cytokines stimulate the differentiation of the respective precursors into osteoblasts and osteoclasts. Thus the aim of the study was to evaluate the level of INTERLEUKIN – 10 in GINGIVAL CEVICULAR FLUID (GCF) during orthodontic tooth movement with the methodology of assessment using ELISA technique.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Bone remodelling ; Interleukin – 10 ; Gingival Crevicular Fluid ; ELISA technique. |
| Subjects: | DENTAL > Orthodontics and Dentofacial Orthopedics |
| Depositing User: | Subramani R |
| Date Deposited: | 12 Nov 2017 15:21 |
| Last Modified: | 12 Nov 2017 15:21 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3911 |
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