Srinivasa Chaitanya, P (2012) Design and Development of Immediate Release and Sustained Release Bi-Layered Matrix Tablets of Oral-Hypoglycemic Drugs. Masters thesis, KMCH College of Pharmacy, Coimbatore.
|
Text
26107116 Srinivasa Chaitanya P.pdf Download (1MB) | Preview |
Abstract
The aim of the work is to develop Bi-layered matrix tablets containing a Biguanide (API I) in SR layer and a Thiazolidinedione (API II) in IR layer. The formula is developed by taking In-vitro release of both the drugs in to consideration. HPMC K 4M, HPMC K 15M and HPMC K 100M were used as rate retarding polymers and Croscarmellose sodium as superdisintegrant for SR layer and IR layer respectively, in the trials for preparing an optimum formulation of the Bi-Layer tablets. Pre-formulation studies and Compatibility studies were found to be satisfactory. Tablet blend all formulations was evaluated for flow properties, which were found to be optimum. Tablet prepared were evaluated for several parameters like Thickness, Hardness, Weight variation, Friability, Drug content and In-vitro release of the drugs. Formulation F-7 was found to be an optimum formula with the release of the API I and API II within specifications. The release rate was found to be following First-order kinetics and mechanism is by combination of diffusion and erosion. Stability studies at conditions 30°C/ 65%RH and 40°C/75%RH are showing that the dosage form is intact after storage for 3 months at both the conditions. It can be concluded that Bi-layered tablets of these drugs are advantageous in having uniform drug content of both the drugs and the sustained release of the API I reduces the dosing frequency thereby improving patient compliance.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Bi-Layered Matrix Tablets; Oral-Hypoglycemic Drugs |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 11 Oct 2017 09:53 |
| Last Modified: | 11 Oct 2017 09:53 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3621 |
Actions (login required)
 |
View Item |
