Devareddy, Sandeep (2012) Formulation and Evaluation of Losartan Potassium and Hydrochlorthiazide Conventional Tablets. Masters thesis, J K K Nattraja College of Pharmacy, Komarapalayam.
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Abstract
This study is to formulate an conventional release oral solid dosage form of Losartan potassium and hydrochlorthiazide which is considered to be stable, robust quality and pharmaceutically equivalent to that of the reference [marketed] product for the treatment of Hypertension.The aim is to develop and evaluate immediate release tablets with different compositions of excipients which will meet the standards to that of the reference product with the subsequent achievement of invitro correlation with the reference product. The stable robust quality of losartan potassium and hydrochlorthiazide conventional tablets are formulated. The formulated tablets are compared with the specifications of the innovator and the optimised formulation complies with the specifications. The disintegrant used in the formulation is low substituted hydroxyl propyl cellulose which is different from that of the innovator and even the binder differs from the innovator even though the specifications of the evaluation are complied as per the specifications. The optimised formulation is kept for stability studies and the results are good.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Losartan Potassium; Hydrochlorthiazide Conventional Tablets; Hydroxyl propyl cellulose |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 23 Aug 2017 11:46 |
| Last Modified: | 23 Aug 2017 11:46 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2814 |
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