Abinaya, M (2019) Formulation Development of Dry Powder Inhalation of Amino Acids for Smoking Cessation. Masters thesis, Karpagam College of Pharmacy, Coimbatore.
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Abstract
This study targets lungs with the aim of producing an effective, and compliant therapy by the rational use of amino acids which plays an important role in the alteration of mood and behaviour during smoking and other activities. L Tryptophan and L Tyrosine were micronized in the size range of 2-4μm with Lactose as carrier and dry powder inhalation was formulated. The combination of these two amino acids may produce a synergistic effect targeting to minimise the withdrawal symptoms associated with the treatment of smoking cessation. In vivo study results showed rapid onset of action, higher local drug concentration, longer retention of drug in the site of administration. Overall this study reports concluded that the formulation of dry powder inhalation offers an effective drug delivery to the lungs when compared with other routes of administration, thus leads to patient compliance and adherence to the therapy.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 261711401 |
| Uncontrolled Keywords: | Formulation, Development, Dry Powder Inhalation, Amino Acids, Smoking Cessation. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 31 Mar 2022 05:53 |
| Last Modified: | 31 Mar 2022 05:54 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/19125 |
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