Shrisaranya, M (2017) An open pilot clinical study on “Uthiravatha Suronitham” (Rheumatoid Arthritis) with the evaluation of Siddha trial drugs “Gandhaga Rasayanam” (Internal) and “Navanatha Sittha Thailam” (External). Masters thesis, Government Siddha Medical College, Chennai.
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Abstract
Uthiravatha suronitham is one among the 80 types of vatha diseases classified by Yugimuni. In modern, uthira vatha suronitham is being co-related with rheumatoid arthritis. The main aim of this study was to prove the efficacy of gandhaga rasayanam and navanatha sittha thailam in uthiravatha suronitham. Before Clinical trail pre clinical analysis such as physiochemical analysis, toxicity studies, antimicroibial studies and pharmacological studies were carried out. Clinically 40 cases which was diagnosed with RA were selected and treated with the trail drugs gandhaga rasayanam [internal], and navanathasittha thailam [external]. Before starting the treatment, the patients were given clear and complete information regarding the treatment protocol and dietary regimens. Initially the patient was advised to undergo purgation before starting the treatment. Later the trail drugs gandhaga rasayanam [internal] and navanathasittha thailam [external] was administered to the patients for a period of 48days [1 mandalam]. During the period of treatment the patients were under dietary regimen (dos and donts for vatha disease). Daily changes of the patients were monitored and recorded. In case of adverse drug reactions, the case was being withdrawn from the treatment. From this study, it is proved that the gandhaka rasayanam and navanathasittha tailam has a good therapeutic effect over uthiravatha suronitham. The results of the outcome of the trail medicines by grading methods were as follows: Good improvement - 80%, Moderate improvement -12.5%, Mild improvement -7.5%, No improvement – 0%. CONCLUSION: Uthiravatha suronitham is being co-related to rheumatoid arthritis in modern medicine. Rheumatoid arthritis is a chronic inflammatory, destructive and deforming, symmetrical poly arthritis associated with symmetrical involvement of joints. Uthiravatha suronitham mainly occurs due to de- arrangement of vatha and pitta dosham. The Toxicological studies reveals that the trial drug doesn’t show any toxicity in rat models. The pre-clinical studies shows that the trail drug has got significant Anti-inflammatory against carageenan induced paw edema method and Analgesic action against acetic acid induced writhing test. The clinical study proves remarkable decrease in the symptoms of the disease. The biostatistical analysis declares that the effect of the trial drug is remarkable. The study proves the therapeutic effect of the drug gandhaga rasayanam (int) and navanathasittha tailam (ext) over morning stiffness, pain, swelling, restricted movements, etc. were significant and no adverse effects were reported during the course of treatment. After undergoing the treatment, the patients were able to do their daily routine by themselves without any others help. The main aim of the treatment was to normalize the de-arranged dosham and to retrieve from the symptoms and overall quality of life.
| Item Type: | Thesis (Masters) |
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| Additional Information: | (Reg.No. 321213103) |
| Uncontrolled Keywords: | Uthiravatha Suronitham ; Rheumatoid Arthritis ; Siddha trial drugs ; Gandhaga Rasayanam ; Navanatha Sittha Thailam ; open pilot clinical study. |
| Subjects: | AYUSH > Sirappu Maruthuvam |
| Depositing User: | Subramani R |
| Date Deposited: | 02 Oct 2018 14:02 |
| Last Modified: | 02 Oct 2018 14:02 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/9641 |
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