Nirmaladevi, P (2014) Comparing the accuracy of 12 hours urine protein with 24 hours urine protein in predicting proteinuria in hypertensive disorders of pregnancy. Masters thesis, Stanley Medical College, Chennai.
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Abstract
BACKGROUND AND OBJECTIVES: Hypertensive disorders complicate 5-10% of all pregnancies. Preeclampsia is diagnosed when hypertension and proteinuria occur after 20 weeks of gestation. . Proteinuria is an important sign of preeclampsia. . It is directly proportional to maternal and perinatal morbidity and mortality. Severity of preeclampsia is also determined by the degree of proteinuria hence accurate and rapid quantification of proteinuria is essential for the diagnosis and management of hypertensive disorders. The objective of this study is to evaluate whether the gold standard 24 hours urine protein can be replaced by 12 hours urine protein. METHODS: This is a prospective study conducted in 100 pregnant women with hypertensive disorders of pregnancy at RSRM hospital. For each woman two 12 hr samples are collected. The protein concentration in the 12 hr and 24 hr samples analyzed by pyrogallol Red Method. RESULTS: Protein collection in a 12 hours sample was fitted closely with the 24 hours collection. A 12 hrs protein > 165 mg correlates with 24 protein of >300 mg. This study shows a correlation coefficient of r =0.94, P value of <0.001, sensitivity of 98%, specificity of 94%, positive predictive value of 97%, negative predictive value of 99%. CONCLUSION: The correlation of 12 hours urine protein with 24 hours urine protein in all degrees of proteinuria suggests that 12 hours protein can be used as an alternative to 24 hours urine protein in predicting proteinuria in hypertensive disorders of pregnancy.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Preeclampsia ; 12 and 24 hrs urine protein ; proteinuria ; pyrogallol red method. |
| Subjects: | MEDICAL > Obstetrics and Gynaecology |
| Depositing User: | Devi S |
| Date Deposited: | 24 Jun 2018 10:03 |
| Last Modified: | 24 Jun 2018 10:03 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/8593 |
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