Deve Ramya, C (2008) Lipid profile changes in pregnancy induced hypertension: A Case control study. Masters thesis, Kilpauk Medical College, Chennai.
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Abstract
There is no significant change in the age distribution between the two groups. 53% of the patients in Group I and 56% of patients in Group II were in the age group of 21 - 25 years. Only 2% of patients in Group I and 4% of patients in Group II were in the age group of 31 - 35 years. (2)The booking status of both the study group and the control group were the same, 92% being booked and 8% being unbooked. (3)47% of patients in Group I and 51% of patients in Group II were primigravida, while only 4% in Group I and 2% in Group II were Gravida 4. (4)12% of patients in group I and 5% of patients in Group II had H/o PIH in the previous pregnancy. (5) It is found that, patients with pregnancy induced hypertension (Group I) had high BMI than their normal counterparts (Group II). (6)The mean total cholesterol level is higher in group I than in Group II. (7)The mean HDL levels are higher in Group I compared to Group II. (8)The mean VLDL values are higher in Group I compared to Group II. (9)The mean triglyceride levels show a significant rise in Group I compared to that of Group II. (10)The mean LDL levels are also increased in Group I compared to that of Group II. (11)65% of patients in Group I and 69% of patients in Group II had normal vaginal delivery. (12)It is found that the obese patients or the patients with high BMI in Group I had elevated triglycerides than those with normal BMI in the same group. Similarly, the patients with high BMI / Obese patients in Group II also had elevated triglycerides than the normal, in Group II. (13)Among the non obese group, the PIH patients in Group I had increased triglycerides compared to the normal women in Group II. Among the obese group also, the mean triglyceride values were higher in patients with pregnancy induced hypertension compared to the normotensive pregnant women. (14)Among the population in Group I, 73% of the women were Hindus, 15% were Muslims and 12% were Christians. Among the population in Group II, 88% of the women were Hindus, 4% were Muslims and 8% were Christians. (15)Among the population in Group I, 80% of Muslims, 66%, of Christians and 30% of Hindus took more than two serves of non-vegetarian diet per week. In group II, 100% of Muslims, 63% of Christians and 40% of the Hindus took more than two serves of non-vegetarian diet per week. (16)Among the population in Group I, 73% of Muslims, 48% of Hindus and 58% of Christians had elevated triglyceride levels. Among the population in Group II, 25% Muslims, 12.5% of Christians and 21.5% of Hindus had elevated triglyceride levels. (17)Among Group I, 88% of persons taking more than two serves of non-vegetarian diet had elevated triglyceride levels. (18)Among Group II, 27.2% of persons taking more than 2 serves of non-vegetarian diet per week had elevated triglyceride levels. CONCLUSION: Analysing and comparing the results between the study group and the control group, it was concluded that : 53% of the study group were in the age group of 21 - 25 years. 47% of the study group were primigravida. BMI was elevated in the PIH group. Triglycerides and LDL were elevated in the PIH group, compared with the control group. The obese group with elevated BMI had elevated triglyceride levels. Thus there exists a consistent positive association between elevated maternal triglyceride and the risk of preeclampsia. Given that the maternal hypertriglyceridemia is a common feature of the metabolic syndrome, interventional studies are needed to determine whether pre -pregnancy weight reduction and dietary modification can lower the risk of preeclampsia. The matter of whether triglycerides share a causative relationship with preeclampsia should be expanded to the study of other lipoprotein particles and microparticles, as well as a detailed analysis of the microvascular bed of the delivered placenta. The collection of blood specimens in early pregnancy measuring concentrations of insulin, glucose and inflammatory markers, alongside anthropometrics assessment and then followed by a thorough assessment of clinical outcomes through a large cohort study might optimally address the role of triglycerides and the metabolic syndrome in the causation of preeclampsia. Clearly, there is a need to establish whether preconception dietary modification, such as adoption of a Mediterranean diet among obese women, can reduce the future risk of preeclampsia and other placenta mediated diseases, including placental abruption and foetal intrauterine growth restriction.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Lipid profile ; pregnancy induced hypertension ; Case control study. |
| Subjects: | MEDICAL > Obstetrics and Gynaecology |
| Depositing User: | Subramani R |
| Date Deposited: | 08 Dec 2017 01:44 |
| Last Modified: | 05 Oct 2019 01:58 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/4276 |
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