Ushakanthan, S (2016) Safety and Pharmacological Profile of Seenthil Chooranam. Masters thesis, National Institute of Siddha, Chennai.
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Abstract
The study of siddha Medicine of Seenthil Chooranam,was converted in to animal dose by using standard method suggested by Pharmacologist. Based on OECD 423 the trail drug Seenthil Chooranam was studied and it is non toxic up to the dose of 2000mg/kg. Gross and histopathological examination of organs of animals administered with highest dose showed normal histological architecture. This could be confirmed as no-observed-adverse-effect level (NOAEL) on acute, 28 days repeated oral and 90 days repeated oral toxicity studies.The Seenthil chooranam is being used for various therapeutic conditions in siddha system of medicines. This study also proved the following pharmacological activities, Seenthil Chooranam was prepared as per the siddha literature.When it was subjected into analysis it fulfills all the standardization parameters of chooranam as mentioned in AYUSH guidelines, From the results of SEM images it confirms the spherical shape and aggregated particle morphology obtained for this Seenthil Chooranam sample.Based on OECD 423 the trail drug Seenthil Chooranamis considered as non toxic up to the dose of 2000mg/kg. This observation reveals that the LD50 of Seenthil chooranam is greater than 2000mg/kg.Seenthil Chooranam could be confirmed as no-observed-adverse-effect level (NOAEL) drug as it acts harmlessly under the current normal usage and this phenomenon is considered to be non toxic.The Anti-Diabetic, Hepatoprotective and Anti-Inflammtory activity of SEENTHIL CHOORANAM was scientifically validated in animal models.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Safety; Seenthil Chooranam |
| Subjects: | AYUSH > Gunapadam |
| Depositing User: | Ravindran C |
| Date Deposited: | 03 Aug 2017 06:15 |
| Last Modified: | 03 Aug 2017 06:15 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2479 |
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