Harini, K (2014) Method Development and Validation for the Simultaneous Estimation of Quinapril and Hydrochlorothiazide in Bulk and Tablet Dosage form By Rp-Hplc. Masters thesis, Swamy Vivekanandha College of Pharmacy, Tiruchengode.
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Abstract
Analytical chemistry plays an increasingly important role in the pharmaceutical industry where, aside from QA, it is used in discovery of new drug candidates and in clinical applications where understanding the interactions between the drug and the patient are critical. Analytical chemistry is defined as the science and art of determining the composition of material in terms of elements or compounds contained in it1 . Analytical chemistry is divided into two branches quantitative and qualitative.. A qualitative method is the information about the identity of atomic or molecular species or functional groups in the sample. A quantitative method provides numerical information as to the relative amount of one or more of these components. In the present study, new RP-HPLC method for simultaneous estimation of Hydrochlorothiazide and Quinapril in bulk and pharmaceutical dosage form was developed. The developed method was validation for various parameters such as accuracy, precision, ruggedness, linearity, robustness, system suitability, specificity, limit of detection and limit of quantitation as per ICH guidelines. The developed method was simple, precise and cost effective for the simultaneous estimation of Hydrochlorothiazide and Quinapril for routine quality control analysis of these either in bulk and pharmaceutical formulation. The developed method was superior when compared to the reported method with less retention time and composition of the mobile phase with good separation.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Simultaneous; Quinapril; Hydrochlorothiazide; Tablet Dosage |
| Subjects: | PHARMACY > Pharmaceutical Analysis |
| Depositing User: | Ravindran C |
| Date Deposited: | 27 Jul 2017 07:12 |
| Last Modified: | 06 Oct 2017 03:38 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2245 |
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