Diana, M Mathew (2021) Formulation and In-vitro Characterization of Cilnidipine Floating Tablets Using Release Retarding Hydrophilic Polymers. Masters thesis, J.K.K.Nattraja College of Pharmacy, Kumarapalayam.
Full text not available from this repository.Abstract
The present study involves the formulation and evaluation of gastroretentive drug delivery of cilnidipine tablets. This type of drug delivery helps to retain the drug in the stomach. The swelling property of the formulation helps to retain the drug in the stomach, by swelling to such an extent so that cannot pass out of the stomach. Pre formulation studies which include Organoleptic properties, Bulk and Tapped densities, Carr’s index, Hausner’s ratio, Melting point, Solubility, were carried out are as per IP specifications. FTIR -Drug-excipient compatibility studies were performed which shows that there is no interaction between drug and polymers. Evaluation studies have been performed for tablets include friability, hardness, weight variation, content uniformity, buoyancy studies are as per IP specifications. Drug release studies have been performed by using 0.1N HCL for 12 hrs. These studies have shown that the formulation F9 gave better drug release up to 12 hrs. which is formulated with HPMC K100 M and HPMC K15 M. CONCLUSION: The floating tablets of cilnidipine 10 mg was prepared and evaluated. Formulation F9 gave better drug release up to 12 hrs combination of HPMC K100 M and HPMC K15 M. The development of oral prolonged release dosage form with gastroretentive properties. After oral administration, such a floating tablet retained in the stomach and release the drug there in a prolonged manner. May reduce the dose frequency and improves patient compliance.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 261910254 |
| Uncontrolled Keywords: | Formulation, In-vitro Characterization, Cilnidipine Floating Tablets, Release Retarding Hydrophilic Polymers. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 12 Aug 2022 06:40 |
| Last Modified: | 12 Aug 2022 06:40 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/20722 |
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